Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 297213..298013 Replicon chromosome
Accession NZ_CP099871
Organism Escherichia albertii strain 253_2_EW_B

Toxin (Protein)


Gene name ataT Uniprot ID A0A8H9C5V7
Locus tag NIZ24_RS01370 Protein ID WP_000342455.1
Coordinates 297486..298013 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag NIZ24_RS01365 Protein ID WP_001277106.1
Coordinates 297213..297479 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ24_RS01345 (292809) 292809..293867 + 1059 WP_001042000.1 permease-like cell division protein FtsX -
NIZ24_RS01350 (294112) 294112..294966 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NIZ24_RS01355 (295163) 295163..295672 + 510 WP_059235675.1 hypothetical protein -
NIZ24_RS01360 (295960) 295960..297063 + 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NIZ24_RS01365 (297213) 297213..297479 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NIZ24_RS01370 (297486) 297486..298013 + 528 WP_000342455.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NIZ24_RS01375 (298010) 298010..298393 - 384 WP_059235673.1 aspartate 1-decarboxylase autocleavage activator PanM -
NIZ24_RS01380 (298817) 298817..299926 + 1110 WP_059235672.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NIZ24_RS01385 (299974) 299974..300900 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NIZ24_RS01390 (300897) 300897..302174 + 1278 WP_044709902.1 branched chain amino acid ABC transporter permease LivM -
NIZ24_RS01395 (302171) 302171..302938 + 768 WP_044709901.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19607.47 Da        Isoelectric Point: 6.6343

>T249567 WP_000342455.1 NZ_CP099871:297486-298013 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT249567 WP_001277106.1 NZ_CP099871:297213-297479 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References