Detailed information of TA system TA024956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 3410280..3410827
• Replicon: chromosome
• Accession: NC_014640
• Organism: Achromobacter xylosoxidans A8

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: AXYL_RS15765
• Protein ID: WP_193353250.1
• Coordinates: 3410501..3410827 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: E3HET3
• Locus tag: AXYL_RS15760
• Protein ID: WP_013393807.1
• Coordinates: 3410280..3410504 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXYL_RS15745	3405923..3407296	+	1374	WP_013393804.1	MmgE/PrpD family protein	-
AXYL_RS15750	3407320..3409383	-	2064	WP_013393805.1	TonB-dependent copper receptor	-
AXYL_RS15755	3409624..3410028	-	405	WP_013393806.1	DUF2946 family protein	-
AXYL_RS15760	3410280..3410504	+	225	WP_013393807.1	antitoxin MazE family protein	Antitoxin
AXYL_RS15765	3410501..3410827	+	327	WP_193353250.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
AXYL_RS15770	3410899..3411528	+	630	WP_013393809.1	glutathione S-transferase N-terminal domain-containing protein	-
AXYL_RS15775	3411801..3412391	+	591	WP_013393810.1	YceI family protein	-
AXYL_RS15780	3412449..3412934	-	486	WP_013393811.1	hypothetical protein	-
AXYL_RS15785	3412950..3413336	-	387	WP_013393812.1	hypothetical protein	-
AXYL_RS15790	3413787..3415085	+	1299	WP_049797931.1	amino acid permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

• Antitoxin MazE-like (8-72)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11621.68 Da
• Isoelectric Point: 9.3440

>T24956 WP_193353250.1 NC_014640:3410501-3410827 [Achromobacter xylosoxidans A8]
MMRGELVTVVAQGDFGKPRPALVIQADLFSEHGSITVLPVTSSLVEAPLLRVNARPTAQNGLQQLSQIMVDKALTVRRDK
LGPAFGRIEAATLLEVERCLAVFIGIAK

Nucleotide

• Length: 327 bp

>T24956 NC_014640:3410501-3410827 [Achromobacter xylosoxidans A8]
CTGATGCGCGGCGAACTGGTGACAGTCGTGGCGCAAGGCGATTTTGGCAAACCGCGTCCGGCCCTGGTCATTCAGGCTGA
CCTGTTCAGCGAACATGGAAGCATCACCGTCCTGCCGGTGACCAGCAGTCTGGTCGAGGCTCCCTTGCTGCGGGTCAACG
CAAGGCCGACTGCTCAGAACGGTTTGCAACAGCTATCTCAAATCATGGTCGACAAGGCGCTAACCGTAAGGCGGGACAAG
CTTGGCCCTGCTTTCGGCCGCATCGAGGCTGCAACGCTGCTGGAAGTCGAGCGCTGTCTGGCCGTCTTTATTGGAATCGC
CAAGTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8450.58 Da
• Isoelectric Point: 7.3611

>AT24956 WP_013393807.1 NC_014640:3410280-3410504 [Achromobacter xylosoxidans A8]
MVTSSVNARVNKHRTALRMAGLRPVQIWVPDTRRPDFAEECLRQSRLATEADAADHATHRLMHQAMSELEGWEP

Nucleotide

• Length: 225 bp

>AT24956 NC_014640:3410280-3410504 [Achromobacter xylosoxidans A8]
ATGGTGACATCCAGTGTGAACGCCCGCGTCAACAAGCATCGCACCGCGCTGCGCATGGCCGGCTTGCGTCCGGTCCAGAT
CTGGGTGCCTGATACCCGACGGCCGGATTTCGCCGAGGAATGCCTGAGGCAATCGCGCCTGGCGACCGAGGCCGATGCGG
CAGATCACGCAACGCATCGCCTGATGCATCAGGCGATGTCCGAGCTGGAAGGCTGGGAGCCCTGA

Structures

Antitoxin

• AlphaFold DB: E3HET3