Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3536293..3536911 Replicon chromosome
Accession NZ_CP099868
Organism Escherichia albertii strain 254_1_EW_B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ25_RS17280 Protein ID WP_001280991.1
Coordinates 3536693..3536911 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIZ25_RS17275 Protein ID WP_000344798.1
Coordinates 3536293..3536667 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ25_RS17265 (3531373) 3531373..3532566 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIZ25_RS17270 (3532589) 3532589..3535738 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ25_RS17275 (3536293) 3536293..3536667 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIZ25_RS17280 (3536693) 3536693..3536911 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ25_RS17285 (3537088) 3537088..3537645 + 558 WP_000093561.1 maltose O-acetyltransferase -
NIZ25_RS17290 (3537753) 3537753..3538223 + 471 WP_059224581.1 YlaC family protein -
NIZ25_RS17295 (3538387) 3538387..3539937 + 1551 WP_256876043.1 EAL domain-containing protein -
NIZ25_RS17300 (3539975) 3539975..3540328 - 354 WP_000878151.1 DUF1428 family protein -
NIZ25_RS17310 (3540709) 3540709..3541020 + 312 WP_000409915.1 MGMT family protein -
NIZ25_RS17315 (3541050) 3541050..3541622 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249551 WP_001280991.1 NZ_CP099868:3536693-3536911 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249551 WP_000344798.1 NZ_CP099868:3536293-3536667 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References