24955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4155421..4156057 Replicon chromosome
Accession NC_014639
Organism Bacillus atrophaeus 1942

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag BATR1942_RS20340 Protein ID WP_003156187.1
Coordinates 4155707..4156057 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A837XXL9
Locus tag BATR1942_RS20335 Protein ID WP_003328141.1
Coordinates 4155421..4155702 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BATR1942_RS20315 4151717..4152316 - 600 WP_003328136.1 rhomboid family intramembrane serine protease -
BATR1942_RS20320 4152416..4152781 + 366 WP_003328138.1 holo-ACP synthase -
BATR1942_RS20325 4152949..4153965 + 1017 WP_087941846.1 outer membrane lipoprotein carrier protein LolA -
BATR1942_RS20330 4154133..4155302 + 1170 WP_003328140.1 alanine racemase -
BATR1942_RS20335 4155421..4155702 + 282 WP_003328141.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
BATR1942_RS20340 4155707..4156057 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BATR1942_RS20345 4156173..4156991 + 819 WP_003328142.1 STAS domain-containing protein -
BATR1942_RS20350 4156996..4157361 + 366 WP_010789626.1 RsbT antagonist protein RsbS -
BATR1942_RS20355 4157364..4157765 + 402 WP_003328144.1 serine/threonine-protein kinase RsbT -
BATR1942_RS20360 4157777..4158784 + 1008 WP_003328145.1 PP2C family protein-serine/threonine phosphatase -
BATR1942_RS20365 4158844..4159173 + 330 WP_003328146.1 anti-sigma factor antagonist RsbV -
BATR1942_RS20370 4159170..4159652 + 483 WP_003328147.1 anti-sigma B factor RsbW -
BATR1942_RS20375 4159618..4160406 + 789 WP_003328149.1 RNA polymerase sigma factor SigB -
BATR1942_RS20380 4160406..4161005 + 600 WP_003328150.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T24955 WP_003156187.1 NC_014639:4155707-4156057 [Bacillus atrophaeus 1942]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T24955 NC_014639:4155707-4156057 [Bacillus atrophaeus 1942]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGAGTGCGCCCGGT
TTTGGTGATTCAAAATGATATCGGAAATCGCTTTAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATTTTGCTGGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATTAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10451.83 Da        Isoelectric Point: 5.1903

>AT24955 WP_003328141.1 NC_014639:4155421-4155702 [Bacillus atrophaeus 1942]
MSESSATTEMMISLPEALVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT24955 NC_014639:4155421-4155702 [Bacillus atrophaeus 1942]
TTGTCTGAATCCAGCGCAACAACCGAAATGATGATTAGCTTGCCGGAAGCACTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTAATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGCACAACTCGTCACAACC
GTGATTTGATGAGACGCGGATATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAAGCTCATTTTGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
AlphaFold DB A0A837XXL9

References