Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2453729..2454333 Replicon chromosome
Accession NZ_CP099868
Organism Escherichia albertii strain 254_1_EW_B

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NIZ25_RS12070 Protein ID WP_059225486.1
Coordinates 2453947..2454333 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag NIZ25_RS12065 Protein ID WP_001195490.1
Coordinates 2453729..2453950 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ25_RS12050 (2449979) 2449979..2451430 + 1452 WP_000854601.1 tagaturonate reductase -
NIZ25_RS12055 (2451635) 2451635..2452549 + 915 WP_024164792.1 bestrophin family protein -
NIZ25_RS12060 (2452553) 2452553..2453311 - 759 WP_233991857.1 trans-aconitate 2-methyltransferase -
NIZ25_RS12065 (2453729) 2453729..2453950 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIZ25_RS12070 (2453947) 2453947..2454333 + 387 WP_059225486.1 type II toxin-antitoxin system death-on-curing family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-110)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14452.45 Da        Isoelectric Point: 7.3228

>T249547 WP_059225486.1 NZ_CP099868:2453947-2454333 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRICDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT249547 WP_001195490.1 NZ_CP099868:2453729-2453950 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References