24954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 802931..803847 Replicon chromosome
Accession NC_014639
Organism Bacillus atrophaeus 1942

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7U5BWH7
Locus tag BATR1942_RS03960 Protein ID WP_003327423.1
Coordinates 803101..803847 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7U5D589
Locus tag BATR1942_RS03955 Protein ID WP_013390483.1
Coordinates 802931..803101 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BATR1942_RS03920 797932..799671 + 1740 WP_003327433.1 pyocin knob domain-containing protein -
BATR1942_RS03925 799688..800017 + 330 WP_003327431.1 XkdW family protein -
BATR1942_RS03930 800014..800178 + 165 WP_003327430.1 XkdX family protein -
BATR1942_RS03935 800254..801102 + 849 WP_003327428.1 hypothetical protein -
BATR1942_RS03940 801175..801453 + 279 WP_003327427.1 hemolysin XhlA family protein -
BATR1942_RS03945 801466..801729 + 264 WP_003327426.1 phage holin -
BATR1942_RS03950 801742..802635 + 894 WP_003327425.1 N-acetylmuramoyl-L-alanine amidase -
BATR1942_RS21460 802711..802833 - 123 WP_010788356.1 hypothetical protein -
BATR1942_RS03955 802931..803101 - 171 WP_013390483.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
BATR1942_RS03960 803101..803847 - 747 WP_003327423.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BATR1942_RS03965 803956..804954 - 999 WP_003327422.1 inorganic phosphate transporter -
BATR1942_RS03970 804967..805584 - 618 WP_003327421.1 DUF47 domain-containing protein -
BATR1942_RS03975 805872..807188 - 1317 WP_003327418.1 amino acid permease -
BATR1942_RS03980 807608..808558 + 951 WP_003327417.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29110.66 Da        Isoelectric Point: 4.5650

>T24954 WP_003327423.1 NC_014639:c803847-803101 [Bacillus atrophaeus 1942]
MLLFFQIMVWCIMAALGLYVYAVWRFEAKVKEKMFAIRKTWYLIFVIGAMVYWTYDPSSLFREWTNYLIVAVSFALIDAF
IFLSAYVKKLAGNELETDTREILEENNEMLHVYLDKLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CEYSTQLEKDRLTEHMDDAFEVQSRLDRKDVYYDQHGKLALIPFTVQTRSYVIKLASDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGDG

Download         Length: 747 bp

>T24954 NC_014639:c803847-803101 [Bacillus atrophaeus 1942]
ATGCTTTTATTCTTTCAGATTATGGTTTGGTGCATAATGGCCGCATTAGGCCTATACGTATATGCGGTGTGGCGGTTTGA
AGCAAAGGTGAAAGAAAAAATGTTTGCGATCCGGAAAACGTGGTATTTGATCTTTGTCATCGGTGCCATGGTATACTGGA
CGTATGACCCCTCTTCCCTTTTCAGGGAATGGACGAATTATTTGATTGTCGCTGTCAGCTTTGCTTTGATTGACGCCTTT
ATCTTTTTGAGCGCTTACGTAAAGAAACTTGCCGGCAATGAATTAGAAACCGACACACGGGAAATCCTTGAAGAAAACAA
TGAAATGCTCCACGTTTATCTTGATAAATTAAAAACGTACCAATACCTATTGAAAAATGAACCGATCCATGTTTATTATG
GAAGTATAGAAGCATACGCTGAGGGCATCGACAAGCTGCTCAAAACCTATGCCGACAAAATGAACTTAACGGCTTCGCTG
TGTGAATATTCGACACAGCTTGAAAAAGACCGCTTAACCGAGCATATGGATGATGCATTTGAGGTGCAGAGCCGGCTGGA
TCGAAAAGATGTATACTATGATCAGCACGGGAAGCTGGCACTCATCCCTTTTACAGTCCAGACACGCAGCTACGTCATCA
AGCTGGCGTCAGACAGCATTGTAACAGAATTTGATTATTTGCTTTTCACATCATTAACTAGCATTTACGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGACGGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6639.60 Da        Isoelectric Point: 11.0258

>AT24954 WP_013390483.1 NC_014639:c803101-802931 [Bacillus atrophaeus 1942]
MERAFQNDHSTRTAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT24954 NC_014639:c803101-802931 [Bacillus atrophaeus 1942]
ATGGAACGTGCTTTTCAAAACGATCATTCGACCCGCACGGCTAAACCGTTTAAGATATTAAAAAAGAGATCAACCACCAG
CGTCGCAAGCTATCAGGTCAGCCCCCACACGGCAAGAATTTTCAAAGAAAATGAGCGGCTGATTGACGAGTATAAAAGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5BWH7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5D589

References