Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 889958..890609 Replicon chromosome
Accession NZ_CP099868
Organism Escherichia albertii strain 254_1_EW_B

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag NIZ25_RS04290 Protein ID WP_000244763.1
Coordinates 890205..890609 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag NIZ25_RS04285 Protein ID WP_059224144.1
Coordinates 889958..890224 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ25_RS04260 (885658) 885658..887091 - 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -
NIZ25_RS04265 (887136) 887136..887447 + 312 WP_098401332.1 N(4)-acetylcytidine aminohydrolase -
NIZ25_RS04270 (887615) 887615..888274 + 660 WP_000250281.1 hemolysin III family protein -
NIZ25_RS04275 (888726) 888726..889706 - 981 WP_059224140.1 tRNA-modifying protein YgfZ -
NIZ25_RS04280 (889738) 889738..889968 + 231 WP_059224142.1 hypothetical protein -
NIZ25_RS04285 (889958) 889958..890224 + 267 WP_059224144.1 FAD assembly factor SdhE Antitoxin
NIZ25_RS04290 (890205) 890205..890609 + 405 WP_000244763.1 protein YgfX Toxin
NIZ25_RS04295 (890643) 890643..891164 - 522 WP_059221135.1 flavodoxin FldB -
NIZ25_RS04300 (891276) 891276..892172 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NIZ25_RS04305 (892197) 892197..892907 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIZ25_RS04310 (892913) 892913..894646 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T249539 WP_000244763.1 NZ_CP099868:890205-890609 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10575.17 Da        Isoelectric Point: 5.1599

>AT249539 WP_059224144.1 NZ_CP099868:889958-890224 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPVDAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure

References