Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1913390..1915026 Replicon chromosome
Accession NZ_CP099856
Organism Acinetobacter baumannii strain 17978S

Toxin (Protein)


Gene name hipA Uniprot ID A0A1E3M7C1
Locus tag NIY04_RS09125 Protein ID WP_000737056.1
Coordinates 1913390..1914721 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NIY04_RS09130 Protein ID WP_001101308.1
Coordinates 1914718..1915026 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY04_RS09105 (NIY04_09105) 1909705..1910865 + 1161 WP_001044492.1 hypothetical protein -
NIY04_RS09110 (NIY04_09110) 1910992..1911963 + 972 WP_109104914.1 5'/3'-nucleotidase SurE -
NIY04_RS09115 (NIY04_09115) 1911975..1912619 + 645 WP_000817301.1 hypothetical protein -
NIY04_RS09120 (NIY04_09120) 1912654..1913094 - 441 WP_000193135.1 HD domain-containing protein -
NIY04_RS09125 (NIY04_09125) 1913390..1914721 + 1332 WP_000737056.1 HipA domain-containing protein Toxin
NIY04_RS09130 (NIY04_09130) 1914718..1915026 + 309 WP_001101308.1 helix-turn-helix domain-containing protein Antitoxin
NIY04_RS09135 (NIY04_09135) 1915752..1916303 + 552 WP_049594830.1 TetR/AcrR family transcriptional regulator -
NIY04_RS09140 (NIY04_09140) 1916519..1917139 + 621 WP_000658761.1 hypothetical protein -
NIY04_RS09145 (NIY04_09145) 1917157..1918239 + 1083 WP_001095788.1 XRE family transcriptional regulator -
NIY04_RS09150 (NIY04_09150) 1918281..1918796 + 516 WP_000914805.1 hypothetical protein -
NIY04_RS09155 (NIY04_09155) 1918944..1919462 + 519 WP_000651611.1 GNAT family N-acetyltransferase -
NIY04_RS09160 (NIY04_09160) 1919443..1919574 + 132 Protein_1781 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.16 Da        Isoelectric Point: 4.7456

>T249534 WP_000737056.1 NZ_CP099856:1913390-1914721 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.55 Da        Isoelectric Point: 9.9701

>AT249534 WP_001101308.1 NZ_CP099856:1914718-1915026 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M7C1

Antitoxin

Source ID Structure

References