Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 457467..458120 Replicon chromosome
Accession NZ_CP099856
Organism Acinetobacter baumannii strain 17978S

Toxin (Protein)


Gene name cptA Uniprot ID A0A1E3M967
Locus tag NIY04_RS02245 Protein ID WP_009518132.1
Coordinates 457731..458120 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag NIY04_RS02240 Protein ID WP_001288210.1
Coordinates 457467..457724 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY04_RS02220 (NIY04_02220) 452982..453989 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
NIY04_RS02225 (NIY04_02225) 454008..454385 + 378 WP_001216380.1 50S ribosomal protein L17 -
NIY04_RS02230 (NIY04_02230) 454567..456057 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
NIY04_RS02235 (NIY04_02235) 456107..457279 - 1173 WP_001190550.1 acyl-CoA dehydrogenase family protein -
NIY04_RS02240 (NIY04_02240) 457467..457724 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
NIY04_RS02245 (NIY04_02245) 457731..458120 + 390 WP_009518132.1 hypothetical protein Toxin
NIY04_RS02250 (NIY04_02250) 458890..459975 + 1086 WP_000049106.1 hypothetical protein -
NIY04_RS02255 (NIY04_02255) 460054..460620 + 567 WP_000651535.1 rhombosortase -
NIY04_RS02260 (NIY04_02260) 460808..463003 + 2196 WP_001158904.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15720.03 Da        Isoelectric Point: 10.4623

>T249532 WP_009518132.1 NZ_CP099856:457731-458120 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Download         Length: 390 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT249532 WP_001288210.1 NZ_CP099856:457467-457724 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M967

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References