Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1902997..1904633 Replicon chromosome
Accession NZ_CP099855
Organism Acinetobacter baumannii strain 17978R

Toxin (Protein)


Gene name hipA Uniprot ID A0A1E3M7C1
Locus tag NIY03_RS09055 Protein ID WP_000737056.1
Coordinates 1902997..1904328 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NIY03_RS09060 Protein ID WP_001101308.1
Coordinates 1904325..1904633 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY03_RS09035 (NIY03_09035) 1899312..1900472 + 1161 WP_001044492.1 hypothetical protein -
NIY03_RS09040 (NIY03_09040) 1900599..1901570 + 972 WP_109104914.1 5'/3'-nucleotidase SurE -
NIY03_RS09045 (NIY03_09045) 1901582..1902226 + 645 WP_000817301.1 hypothetical protein -
NIY03_RS09050 (NIY03_09050) 1902261..1902701 - 441 WP_000193135.1 HD domain-containing protein -
NIY03_RS09055 (NIY03_09055) 1902997..1904328 + 1332 WP_000737056.1 HipA domain-containing protein Toxin
NIY03_RS09060 (NIY03_09060) 1904325..1904633 + 309 WP_001101308.1 helix-turn-helix domain-containing protein Antitoxin
NIY03_RS09065 (NIY03_09065) 1905359..1905910 + 552 WP_049594830.1 TetR/AcrR family transcriptional regulator -
NIY03_RS09070 (NIY03_09070) 1906126..1906746 + 621 WP_000658761.1 hypothetical protein -
NIY03_RS09075 (NIY03_09075) 1906764..1907846 + 1083 WP_001095788.1 XRE family transcriptional regulator -
NIY03_RS09080 (NIY03_09080) 1907888..1908403 + 516 WP_000914805.1 hypothetical protein -
NIY03_RS09085 (NIY03_09085) 1908551..1909069 + 519 WP_000651611.1 GNAT family N-acetyltransferase -
NIY03_RS09090 (NIY03_09090) 1909050..1909181 + 132 Protein_1768 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.16 Da        Isoelectric Point: 4.7456

>T249531 WP_000737056.1 NZ_CP099855:1902997-1904328 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.55 Da        Isoelectric Point: 9.9701

>AT249531 WP_001101308.1 NZ_CP099855:1904325-1904633 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M7C1

Antitoxin

Source ID Structure

References