24953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 126117..127699 Replicon plasmid pYP12
Accession NC_014626
Organism Ketogulonicigenium vulgare Y25

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EIO_RS16015 Protein ID WP_013385709.1
Coordinates 126368..127699 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EIO_RS16010 Protein ID WP_044008278.1
Coordinates 126117..126368 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIO_RS15990 122368..123220 - 853 Protein_112 ABC transporter permease -
EIO_RS15995 123230..124180 - 951 WP_013385705.1 ABC transporter permease -
EIO_RS17675 124199..125167 - 969 WP_162467630.1 hypothetical protein -
EIO_RS16010 126117..126368 + 252 WP_044008278.1 helix-turn-helix domain-containing protein Antitoxin
EIO_RS16015 126368..127699 + 1332 WP_013385709.1 type II toxin-antitoxin system HipA family toxin Toxin
EIO_RS16020 127787..129695 - 1909 Protein_117 response regulator -
EIO_RS16025 129688..130616 - 929 Protein_118 protein-glutamate O-methyltransferase CheR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..243645 243645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(153-410)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-54)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 47632.54 Da        Isoelectric Point: 8.0604

>T24953 WP_013385709.1 NC_014626:126368-127699 [Ketogulonicigenium vulgare Y25]
MGRRRAYPPLDVYMNARLVGQFARQSGGAHLFTYAQSWLDWPGRLPISRALPLQGARHQGAAVIAVFDNLLPDHPQIRDR
LAARVGAGGADAFSLLAEIGRDCVGALQFLPAGEVPDAQGLQADPLSAAQIGALLSNLSAAPLGLDRTRDFRISVAGAQE
KTALLRQGDQWFAPRGATPTTHILKPAIGLLPSGVDLRNAPQNEHFCLRLLAGFGLRVADTQVADFNGLSTLVVTRFDRL
GGGGVTRFDRLWTADGRLIRLPQEDCCQALGVPSSLKYQSDGGPGIREISALLQASDQPVQDRLDFFKANILFWLMGATD
GHAKNFSLSMAPGGRFRLAPLYDVISLQPALAAGQMQPGDMRLAMRMGASRYYRIGDITGRHILESGLDAGLSRVQVLAI
CAEIAESAAAAFEAASDTVQDQEMIAAIRAGFDQRLPRLMTMT

Download         Length: 1332 bp

>T24953 NC_014626:126368-127699 [Ketogulonicigenium vulgare Y25]
ATGGGACGTCGCCGGGCCTATCCGCCATTGGATGTCTATATGAACGCACGTCTTGTCGGGCAGTTTGCGCGGCAAAGCGG
GGGCGCGCATCTGTTCACCTATGCGCAAAGCTGGCTGGACTGGCCGGGCCGGCTGCCGATCTCGCGGGCGTTGCCATTGC
AGGGCGCACGCCATCAAGGCGCGGCGGTGATTGCGGTTTTTGACAACCTGCTGCCCGATCACCCGCAGATCCGCGACCGT
CTGGCGGCGCGGGTCGGGGCGGGCGGTGCGGATGCGTTCAGCCTGCTGGCCGAGATTGGGCGCGATTGCGTCGGCGCGCT
GCAATTTCTGCCAGCGGGCGAGGTGCCTGACGCGCAGGGGCTGCAGGCCGATCCGCTGAGCGCGGCGCAGATTGGCGCGC
TGCTATCGAACCTGAGCGCCGCGCCGCTGGGGCTGGACCGCACGCGGGACTTCCGCATTTCGGTCGCTGGGGCGCAGGAA
AAGACGGCGCTGCTGCGGCAGGGCGATCAGTGGTTCGCGCCGCGCGGGGCGACCCCTACGACCCATATCCTGAAACCCGC
GATCGGGCTGCTGCCCAGTGGGGTCGATCTGCGCAACGCCCCCCAGAACGAGCATTTCTGTCTGCGCCTGCTGGCCGGTT
TCGGTCTGCGCGTGGCTGACACGCAGGTTGCGGATTTCAATGGCCTCAGCACGCTGGTTGTCACCCGGTTTGACCGGCTG
GGGGGGGGGGGGGTCACCCGGTTTGACCGGCTGTGGACGGCGGATGGGCGGTTGATCCGCCTGCCGCAAGAGGATTGCTG
TCAGGCCCTCGGCGTGCCGTCCAGCCTGAAATATCAAAGCGATGGCGGCCCGGGCATCCGCGAGATCAGCGCGCTGTTGC
AGGCCAGCGATCAGCCGGTGCAGGACCGGTTGGATTTTTTCAAGGCGAATATCCTGTTCTGGCTGATGGGCGCGACCGAT
GGCCATGCCAAGAATTTCAGCCTGTCCATGGCCCCCGGCGGGCGGTTCCGGCTGGCACCGCTGTATGATGTGATCAGCCT
GCAACCGGCGCTGGCGGCGGGGCAGATGCAGCCCGGGGATATGCGCCTCGCGATGCGGATGGGGGCAAGCCGCTATTATC
GCATAGGGGATATCACCGGCCGCCATATTCTGGAAAGCGGGCTGGATGCCGGATTGTCGCGGGTGCAGGTCCTGGCGATT
TGCGCTGAGATTGCCGAAAGCGCCGCCGCGGCCTTTGAGGCGGCATCAGACACAGTGCAGGACCAGGAGATGATCGCGGC
GATCCGCGCGGGGTTTGACCAGCGCTTGCCCAGACTGATGACAATGACCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9042.29 Da        Isoelectric Point: 5.6379

>AT24953 WP_044008278.1 NC_014626:126117-126368 [Ketogulonicigenium vulgare Y25]
MDHIIRSPKDIGHVLRQARKAGGLSQADLAAKAGLWQRTVSTLETGAADARLETLFDLLAALDLELQVVPRSRTDPDSFA
DLF

Download         Length: 252 bp

>AT24953 NC_014626:126117-126368 [Ketogulonicigenium vulgare Y25]
ATGGACCATATCATTCGCTCACCCAAAGATATCGGACATGTGCTGCGGCAGGCCCGCAAGGCAGGGGGGCTGTCGCAGGC
TGACCTTGCCGCAAAAGCGGGCCTGTGGCAGCGCACGGTTTCCACGCTGGAAACCGGCGCGGCGGATGCAAGGCTGGAAA
CGCTGTTTGATCTGCTCGCCGCGCTGGATCTGGAATTGCAGGTCGTGCCGCGCAGCCGCACCGATCCCGACAGTTTTGCC
GATCTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References