Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 458646..459299 Replicon chromosome
Accession NZ_CP099855
Organism Acinetobacter baumannii strain 17978R

Toxin (Protein)


Gene name cptA Uniprot ID A0A1E3M967
Locus tag NIY03_RS02245 Protein ID WP_009518132.1
Coordinates 458910..459299 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag NIY03_RS02240 Protein ID WP_001288210.1
Coordinates 458646..458903 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY03_RS02220 (NIY03_02220) 454161..455168 + 1008 WP_253229149.1 DNA-directed RNA polymerase subunit alpha -
NIY03_RS02225 (NIY03_02225) 455187..455564 + 378 WP_001216380.1 50S ribosomal protein L17 -
NIY03_RS02230 (NIY03_02230) 455746..457236 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
NIY03_RS02235 (NIY03_02235) 457286..458458 - 1173 WP_001190550.1 acyl-CoA dehydrogenase family protein -
NIY03_RS02240 (NIY03_02240) 458646..458903 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
NIY03_RS02245 (NIY03_02245) 458910..459299 + 390 WP_009518132.1 hypothetical protein Toxin
NIY03_RS02250 (NIY03_02250) 460069..461154 + 1086 WP_000049106.1 hypothetical protein -
NIY03_RS02255 (NIY03_02255) 461233..461799 + 567 WP_000651535.1 rhombosortase -
NIY03_RS02260 (NIY03_02260) 461987..464182 + 2196 WP_001158904.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15720.03 Da        Isoelectric Point: 10.4623

>T249529 WP_009518132.1 NZ_CP099855:458910-459299 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Download         Length: 390 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT249529 WP_001288210.1 NZ_CP099855:458646-458903 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M967

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References