Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1461319..1461974 Replicon chromosome
Accession NZ_CP099837
Organism Nocardiopsis exhalans strain JCM11759T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NE857_RS06605 Protein ID WP_254420205.1
Coordinates 1461549..1461974 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NE857_RS06600 Protein ID WP_017580610.1
Coordinates 1461319..1461552 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE857_RS06575 (NE857_06575) 1456390..1456977 - 588 WP_254421895.1 hypothetical protein -
NE857_RS06580 (NE857_06580) 1457170..1458618 - 1449 WP_254420201.1 DNA recombination protein RmuC -
NE857_RS06585 (NE857_06585) 1458698..1458976 + 279 WP_254420202.1 hypothetical protein -
NE857_RS06590 (NE857_06590) 1458980..1459945 - 966 WP_254420203.1 FkbM family methyltransferase -
NE857_RS06595 (NE857_06595) 1460114..1461199 + 1086 WP_254420204.1 redox-regulated ATPase YchF -
NE857_RS06600 (NE857_06600) 1461319..1461552 + 234 WP_017580610.1 Arc family DNA-binding protein Antitoxin
NE857_RS06605 (NE857_06605) 1461549..1461974 + 426 WP_254420205.1 type II toxin-antitoxin system VapC family toxin Toxin
NE857_RS06610 (NE857_06610) 1461971..1462171 + 201 WP_254420206.1 GNAT family N-acetyltransferase -
NE857_RS06615 (NE857_06615) 1462875..1463840 + 966 WP_254420207.1 conjugal transfer protein -
NE857_RS06620 (NE857_06620) 1463924..1464247 + 324 WP_017580620.1 hypothetical protein -
NE857_RS06625 (NE857_06625) 1464267..1464521 + 255 Protein_1291 conjugal transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(11-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15155.15 Da        Isoelectric Point: 4.4242

>T249525 WP_254420205.1 NZ_CP099837:1461549-1461974 [Nocardiopsis exhalans]
VIVLDTNVISEIFRPAPEPRVLEWLTSLTDDVAITSITLAELLAGVRRLPDGRRKDVLATRIDEAIEPYRGSRSVLAFDD
IAAERYADVLASRESAGAPISTADAQIAAICLAHDATCATRNVKDFAHTGVEIIDPWAGAS

Download         Length: 426 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8341.46 Da        Isoelectric Point: 6.2165

>AT249525 WP_017580610.1 NZ_CP099837:1461319-1461552 [Nocardiopsis exhalans]
VSSIIVRGLDEHVKQQLAAQAKEHGRSMEAEVRDILTKAARRPHIGLALLSAAQDVGGFDELPVPARNDVARAVDFE

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References