Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 147469..148205 Replicon plasmid unnamed1
Accession NZ_CP099835
Organism Klebsiella quasipneumoniae strain Y7-3

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag NDO72_RS26150 Protein ID WP_003026803.1
Coordinates 147469..147951 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NDO72_RS26155 Protein ID WP_003026799.1
Coordinates 147939..148205 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO72_RS26130 (NDO72_26130) 142568..143733 + 1166 Protein_143 IS3 family transposase -
NDO72_RS26135 (NDO72_26135) 143937..144935 + 999 WP_001610306.1 hypothetical protein -
NDO72_RS26140 (NDO72_26140) 144939..145856 + 918 WP_158003452.1 S-4TM family putative pore-forming effector -
NDO72_RS26145 (NDO72_26145) 145887..147290 - 1404 WP_253231046.1 ISNCY family transposase -
NDO72_RS26150 (NDO72_26150) 147469..147951 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
NDO72_RS26155 (NDO72_26155) 147939..148205 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NDO72_RS26160 (NDO72_26160) 148381..148635 - 255 WP_004152108.1 hypothetical protein -
NDO72_RS26165 (NDO72_26165) 148711..148968 - 258 WP_004152107.1 hypothetical protein -
NDO72_RS26170 (NDO72_26170) 149017..149220 - 204 WP_004152106.1 HHA domain-containing protein -
NDO72_RS26175 (NDO72_26175) 149254..149622 - 369 WP_004152105.1 hypothetical protein -
NDO72_RS26180 (NDO72_26180) 149666..150160 - 495 WP_004152104.1 DNA-binding protein -
NDO72_RS26185 (NDO72_26185) 150191..150766 - 576 WP_004152103.1 hypothetical protein -
NDO72_RS26190 (NDO72_26190) 150754..151023 - 270 WP_004152102.1 hypothetical protein -
NDO72_RS26195 (NDO72_26195) 151381..151731 + 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
NDO72_RS26200 (NDO72_26200) 151781..152143 + 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..170537 170537


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T249522 WP_003026803.1 NZ_CP099835:c147951-147469 [Klebsiella quasipneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT249522 WP_003026799.1 NZ_CP099835:c148205-147939 [Klebsiella quasipneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References