Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4757031..4757547 Replicon chromosome
Accession NZ_CP099834
Organism Klebsiella quasipneumoniae strain Y7-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NDO72_RS22805 Protein ID WP_080820655.1
Coordinates 4757031..4757315 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1C1EW86
Locus tag NDO72_RS22810 Protein ID WP_023291757.1
Coordinates 4757305..4757547 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO72_RS22795 (4754029) 4754029..4756167 + 2139 WP_080820653.1 anaerobic ribonucleoside-triphosphate reductase -
NDO72_RS22800 (4756563) 4756563..4757027 + 465 WP_012969085.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NDO72_RS22805 (4757031) 4757031..4757315 - 285 WP_080820655.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDO72_RS22810 (4757305) 4757305..4757547 - 243 WP_023291757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NDO72_RS22815 (4757625) 4757625..4759535 - 1911 WP_044525201.1 PRD domain-containing protein -
NDO72_RS22820 (4759558) 4759558..4760709 - 1152 WP_101995763.1 lactonase family protein -
NDO72_RS22825 (4760776) 4760776..4761516 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-70)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10957.79 Da        Isoelectric Point: 10.3796

>T249521 WP_080820655.1 NZ_CP099834:c4757315-4757031 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVENPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9119.58 Da        Isoelectric Point: 4.8146

>AT249521 WP_023291757.1 NZ_CP099834:c4757547-4757305 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C1EW86

References