Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2610272..2611860 Replicon chromosome
Accession NZ_CP099834
Organism Klebsiella quasipneumoniae strain Y7-3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NDO72_RS12665 Protein ID WP_064154631.1
Coordinates 2610272..2611594 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2N4W0X3
Locus tag NDO72_RS12670 Protein ID WP_023289667.1
Coordinates 2611594..2611860 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO72_RS12650 (2605310) 2605310..2607829 + 2520 WP_064154629.1 fimbria/pilus outer membrane usher protein -
NDO72_RS12655 (2607817) 2607817..2608821 + 1005 WP_064154630.1 fimbrial protein -
NDO72_RS12660 (2608963) 2608963..2610255 + 1293 WP_044523014.1 glycoside hydrolase family 10 protein -
NDO72_RS12665 (2610272) 2610272..2611594 - 1323 WP_064154631.1 type II toxin-antitoxin system HipA family toxin Toxin
NDO72_RS12670 (2611594) 2611594..2611860 - 267 WP_023289667.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NDO72_RS12675 (2612125) 2612125..2612451 - 327 WP_064154632.1 hydroxyisourate hydrolase -
NDO72_RS12680 (2612448) 2612448..2612948 - 501 WP_032452825.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NDO72_RS12685 (2612926) 2612926..2614305 - 1380 WP_032452824.1 nucleobase:cation symporter-2 family protein -
NDO72_RS12690 (2614651) 2614651..2615805 + 1155 WP_064154633.1 FAD-dependent urate hydroxylase HpxO -
NDO72_RS12695 (2615786) 2615786..2616709 - 924 WP_044522995.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49211.54 Da        Isoelectric Point: 8.6110

>T249517 WP_064154631.1 NZ_CP099834:c2611594-2610272 [Klebsiella quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPVDFSAHVWRAITENMLKLHARLQQGLQAR

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9891.25 Da        Isoelectric Point: 7.3163

>AT249517 WP_023289667.1 NZ_CP099834:c2611860-2611594 [Klebsiella quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N4W0X3

References