Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 957967..958590 Replicon chromosome
Accession NZ_CP099815
Organism Yersinia ruckeri strain NVI-11050

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LNQ40_RS04335 Protein ID WP_038243726.1
Coordinates 957967..958170 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LNQ40_RS04340 Protein ID WP_004718732.1
Coordinates 958222..958590 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNQ40_RS04310 (LNQ40_004305) 953822..954160 + 339 WP_007886947.1 P-II family nitrogen regulator -
LNQ40_RS04315 (LNQ40_004310) 954199..955488 + 1290 WP_004718723.1 ammonium transporter AmtB -
LNQ40_RS04320 (LNQ40_004315) 955603..956466 - 864 WP_004718726.1 acyl-CoA thioesterase II -
LNQ40_RS04325 (LNQ40_004320) 956844..957158 - 315 WP_004718728.1 MGMT family protein -
LNQ40_RS04335 (LNQ40_004330) 957967..958170 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
LNQ40_RS04340 (LNQ40_004335) 958222..958590 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LNQ40_RS04345 (LNQ40_004340) 959639..959800 + 162 WP_004718735.1 hypothetical protein -
LNQ40_RS04350 (LNQ40_004345) 959919..960062 - 144 WP_071666974.1 type B 50S ribosomal protein L36 -
LNQ40_RS04355 (LNQ40_004350) 960082..960336 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T249505 WP_038243726.1 NZ_CP099815:c958170-957967 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT249505 WP_004718732.1 NZ_CP099815:c958590-958222 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References