Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
| Location | 465437..467157 | Replicon | chromosome |
| Accession | NZ_CP099815 | ||
| Organism | Yersinia ruckeri strain NVI-11050 | ||
Toxin (Protein)
| Gene name | pmenT | Uniprot ID | - |
| Locus tag | LNQ40_RS02115 | Protein ID | WP_038245758.1 |
| Coordinates | 465437..466093 (+) | Length | 219 a.a. |
Antitoxin (Protein)
| Gene name | pmenA | Uniprot ID | - |
| Locus tag | LNQ40_RS02120 | Protein ID | WP_038245756.1 |
| Coordinates | 466090..467157 (+) | Length | 356 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNQ40_RS02080 (LNQ40_002080) | 461630..462490 | + | 861 | WP_245759121.1 | toll/interleukin-1 receptor domain-containing protein | - |
| LNQ40_RS02085 (LNQ40_002085) | 462566..462874 | + | 309 | WP_038245765.1 | hypothetical protein | - |
| LNQ40_RS02090 (LNQ40_002090) | 462922..463374 | + | 453 | Protein_403 | site-specific integrase | - |
| LNQ40_RS02095 (LNQ40_002095) | 463548..463802 | + | 255 | WP_005175264.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| LNQ40_RS02100 (LNQ40_002100) | 463792..464082 | + | 291 | WP_071666901.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LNQ40_RS02105 (LNQ40_002105) | 464346..464735 | + | 390 | WP_049689831.1 | restriction endonuclease subunit S | - |
| LNQ40_RS02110 (LNQ40_002110) | 464859..465434 | + | 576 | WP_038245760.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| LNQ40_RS02115 (LNQ40_002115) | 465437..466093 | + | 657 | WP_038245758.1 | DUF4433 domain-containing protein | Toxin |
| LNQ40_RS02120 (LNQ40_002120) | 466090..467157 | + | 1068 | WP_038245756.1 | macro domain-containing protein | Antitoxin |
| LNQ40_RS02125 (LNQ40_002125) | 467178..467444 | + | 267 | Protein_410 | hypothetical protein | - |
| LNQ40_RS02130 (LNQ40_002130) | 467463..467861 | - | 399 | Protein_411 | integrase core domain-containing protein | - |
| LNQ40_RS02135 (LNQ40_002135) | 467860..468156 | + | 297 | Protein_412 | integrase core domain-containing protein | - |
| LNQ40_RS02140 (LNQ40_002140) | 468185..468290 | - | 106 | Protein_413 | transposase | - |
| LNQ40_RS02145 (LNQ40_002145) | 468304..468432 | - | 129 | Protein_414 | helix-turn-helix domain-containing protein | - |
| LNQ40_RS02150 (LNQ40_002150) | 468582..468812 | + | 231 | Protein_415 | DUF4942 domain-containing protein | - |
| LNQ40_RS02155 (LNQ40_002155) | 468887..469282 | + | 396 | WP_038245317.1 | DUF6088 family protein | - |
| LNQ40_RS02160 (LNQ40_002160) | 469275..470224 | + | 950 | Protein_417 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| LNQ40_RS02165 (LNQ40_002165) | 470592..470717 | + | 126 | Protein_418 | antirestriction protein | - |
| LNQ40_RS02170 (LNQ40_002170) | 470743..470916 | + | 174 | Protein_419 | type IV toxin-antitoxin system YeeU family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 460436..468156 | 7720 | |
| - | flank | IS/Tn | - | - | 467908..468156 | 248 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 219 a.a. Molecular weight: 25244.74 Da Isoelectric Point: 6.6007
>T249504 WP_038245758.1 NZ_CP099815:465437-466093 [Yersinia ruckeri]
VAYDYSTSLNPEKALIWRIVHRDNIPWILDNGLHCGNSPVQAEDWINIGNPELIDKRAGHLVPTGMRGTLHDYVPFYFTP
FSPMLMNIRSGRGGIKQRPNEEIVILVSSLRNMVAQNVSFVFTDSHAYYNLTNYFTELDSLNQIDWPILQARDFRRDQDD
LAKFERYQAEALIWKHCPIALLGGMICYNDGVRLQLEQWLSQRNLSMPVHARAGWYFS
VAYDYSTSLNPEKALIWRIVHRDNIPWILDNGLHCGNSPVQAEDWINIGNPELIDKRAGHLVPTGMRGTLHDYVPFYFTP
FSPMLMNIRSGRGGIKQRPNEEIVILVSSLRNMVAQNVSFVFTDSHAYYNLTNYFTELDSLNQIDWPILQARDFRRDQDD
LAKFERYQAEALIWKHCPIALLGGMICYNDGVRLQLEQWLSQRNLSMPVHARAGWYFS
Download Length: 657 bp
Antitoxin
Download Length: 356 a.a. Molecular weight: 40846.27 Da Isoelectric Point: 6.6976
>AT249504 WP_038245756.1 NZ_CP099815:466090-467157 [Yersinia ruckeri]
MITFTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPVNMKAYALACKHKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWVEDGLQDLRRFLIKEKVQSIAIPPLGAGNGGLNWSDVRMRIESALGDLQDTEILIYEPTEKYQNVAKST
GVKKLTPARALIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDTQPLDVIWFNDQEKEHINLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGKCQPTLDSVKEG
LHQWPAGERWASRKMKLFDDKNLQFAINRVMEFHC
MITFTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPVNMKAYALACKHKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWVEDGLQDLRRFLIKEKVQSIAIPPLGAGNGGLNWSDVRMRIESALGDLQDTEILIYEPTEKYQNVAKST
GVKKLTPARALIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDTQPLDVIWFNDQEKEHINLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGKCQPTLDSVKEG
LHQWPAGERWASRKMKLFDDKNLQFAINRVMEFHC
Download Length: 1068 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|