249500

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 3125266..3126604 Replicon chromosome
Accession NZ_CP099813
Organism Yersinia ruckeri strain NVI-492

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag LNQ24_RS13990 Protein ID WP_248577550.1
Coordinates 3125266..3126216 (-) Length 317 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A848MNT5
Locus tag LNQ24_RS13995 Protein ID WP_038245317.1
Coordinates 3126209..3126604 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNQ24_RS13970 (LNQ24_013965) 3122075..3122767 - 693 WP_038245321.1 oligogalacturonate-specific porin KdgM family protein -
LNQ24_RS13975 (LNQ24_013970) 3122815..3123969 - 1155 WP_038245380.1 N-acetylneuraminate epimerase -
LNQ24_RS13980 (LNQ24_013975) 3124572..3124745 - 174 Protein_2707 type IV toxin-antitoxin system YeeU family antitoxin -
LNQ24_RS13985 (LNQ24_013980) 3124771..3124896 - 126 Protein_2708 antirestriction protein -
LNQ24_RS13990 (LNQ24_013985) 3125266..3126216 - 951 WP_248577550.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LNQ24_RS13995 (LNQ24_013990) 3126209..3126604 - 396 WP_038245317.1 DUF6088 family protein Antitoxin
LNQ24_RS14000 (LNQ24_013995) 3126679..3126909 - 231 Protein_2711 DUF4942 domain-containing protein -
LNQ24_RS14005 (LNQ24_014000) 3127059..3127187 + 129 Protein_2712 helix-turn-helix domain-containing protein -
LNQ24_RS14010 (LNQ24_014005) 3127201..3127306 + 106 Protein_2713 transposase -
LNQ24_RS14015 (LNQ24_014010) 3127335..3127631 - 297 Protein_2714 transposase -
LNQ24_RS14020 (LNQ24_014015) 3127630..3128028 + 399 Protein_2715 integrase core domain-containing protein -
LNQ24_RS14025 (LNQ24_014020) 3128047..3128333 - 287 Protein_2716 hypothetical protein -
LNQ24_RS14030 (LNQ24_014025) 3128354..3129421 - 1068 WP_038275274.1 macro domain-containing protein -
LNQ24_RS14035 (LNQ24_014030) 3129418..3130074 - 657 WP_096823271.1 DUF4433 domain-containing protein -
LNQ24_RS14040 (LNQ24_014035) 3130077..3130652 - 576 WP_071706520.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
LNQ24_RS14045 (LNQ24_014040) 3130776..3131165 - 390 WP_248577710.1 restriction endonuclease subunit S -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3122815..3131963 9148
- inside IScluster/Tn - - 3127335..3133531 6196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 317 a.a.        Molecular weight: 35942.25 Da        Isoelectric Point: 4.4657

>T249500 WP_248577550.1 NZ_CP099813:c3126216-3125266 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPLDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPLAGFSQ
QYSRGQCKSIRKGIIQTIIETVAASGTFLLDEEYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA

Download         Length: 951 bp


Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14406.76 Da        Isoelectric Point: 11.0360

>AT249500 WP_038245317.1 NZ_CP099813:c3126604-3126209 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Download         Length: 396 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A848MNT5

References