Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4360304..4361999 Replicon chromosome
Accession NC_014618
Organism Enterobacter lignolyticus SCF1

Toxin (Protein)


Gene name mosT Uniprot ID E3G1J7
Locus tag ENTCL_RS20225 Protein ID WP_013367998.1
Coordinates 4360304..4361230 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID E3G1J8
Locus tag ENTCL_RS20230 Protein ID WP_013367999.1
Coordinates 4361217..4361999 (-) Length 261 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTCL_RS20205 4356249..4358165 + 1917 WP_013367994.1 fructose-specific PTS transporter subunit EIIC -
ENTCL_RS20210 4358208..4358894 + 687 WP_013367995.1 GntR family transcriptional regulator -
ENTCL_RS20215 4359020..4359949 + 930 WP_013367996.1 curved DNA-binding protein -
ENTCL_RS20220 4359949..4360248 + 300 WP_013367997.1 chaperone modulator CbpM -
ENTCL_RS20225 4360304..4361230 - 927 WP_013367998.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ENTCL_RS20230 4361217..4361999 - 783 WP_013367999.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
ENTCL_RS20235 4362625..4362825 + 201 WP_044612191.1 hypothetical protein -
ENTCL_RS20240 4363054..4365321 + 2268 WP_013368001.1 arginine decarboxylase -
ENTCL_RS20245 4365595..4366359 + 765 WP_013368002.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-92)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 34910.37 Da        Isoelectric Point: 7.3243

>T24949 WP_013367998.1 NC_014618:c4361230-4360304 [[Enterobacter] lignolyticus SCF1]
MDLRDSYARQVRLLMIALPHAAKEPCFALKGGTAINLFVQDFPRLSVDIDLAYKTFVDRDTDLASINSALMRITESLNRR
PGITAIRQENKADEKRIVVHSTNAQIKIEVSPVWRGLLLPPTEMPVCERVEAEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIVDGFLCYLAGHPRPIAELLAPNWDMAQISTLYSQEFSGMTQQETSLESLLSVTSLLLQAL
KSQLTDRDRQFLLSFKQNNPDWSLYRYPAIQHLPAIRWKLRNLIVLKDKNPAKFAATVDKLERVLDNA

Download         Length: 927 bp

>T24949 NC_014618:c4361230-4360304 [[Enterobacter] lignolyticus SCF1]
ATGGATCTACGTGATAGTTATGCCCGACAGGTCAGGCTATTGATGATTGCTCTGCCGCATGCGGCGAAGGAACCCTGCTT
TGCGCTGAAAGGCGGTACGGCAATCAATTTGTTTGTACAGGATTTTCCCCGTCTGTCGGTGGATATCGATCTGGCCTATA
AGACTTTTGTGGATCGTGATACCGATCTGGCGAGCATCAACAGCGCTTTGATGCGTATTACAGAATCACTCAACCGCAGA
CCGGGGATCACGGCTATCCGGCAGGAGAATAAGGCCGATGAAAAGCGCATCGTCGTCCACTCAACGAATGCGCAGATCAA
GATTGAAGTCAGTCCGGTCTGGCGCGGATTATTGTTACCACCAACAGAAATGCCGGTATGCGAACGGGTAGAAGCGGAAT
ATGGTTTTACAACGATGAATGTCGTTTCACTGGCGGATCTTTACGGCGGTAAAATTTGCGCTGCGCTTGACCGTCAGCAT
CCTCGCGATCTGTTTGATGTTCTCAATATGCTGGAAAAACCGGGCCTGACGCGTGAGATAGTGGATGGTTTTCTCTGTTA
CCTGGCAGGTCACCCTCGCCCCATTGCCGAGTTGCTGGCACCAAACTGGGATATGGCGCAGATCTCCACACTGTACTCAC
AGGAATTTTCCGGGATGACGCAACAAGAAACATCGCTGGAGTCGCTCCTGTCAGTCACCTCGTTGCTGCTGCAGGCGCTG
AAATCTCAGCTTACGGACAGGGATCGCCAGTTTTTACTCAGTTTTAAGCAAAACAATCCTGACTGGTCGCTGTATCGCTA
TCCTGCAATTCAGCATCTCCCGGCGATTCGCTGGAAACTGCGTAATCTGATTGTACTGAAGGATAAAAATCCGGCCAAAT
TCGCGGCGACGGTGGACAAGCTGGAGCGCGTTTTGGATAACGCGTAG

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29436.84 Da        Isoelectric Point: 9.1593

>AT24949 WP_013367999.1 NC_014618:c4361999-4361217 [[Enterobacter] lignolyticus SCF1]
MTSYINWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRLAHGVYCRTGREPDWVDAVYCLQTQWGKQIRVAGLT
SLRLQGYAHYIEPGRPQVWLALPAYVKLPGWFAVFEQSATFVALYTSSLTVDITPFTLELKMGDRRLTGSVSELAAYEIA
CGVPSLISFEHADVLYQGMNLLSPRKLQALLCASHSVKTNRVMLYLAQRNAHPYFQYLNQNGIETGKGKRQIVPGGWLEP
DYQITVPRAFKPEGTDDGST

Download         Length: 783 bp

>AT24949 NC_014618:c4361999-4361217 [[Enterobacter] lignolyticus SCF1]
TTGACAAGTTATATAAACTGGCTTATGCAGAACACCCTTCCCGGCCAGGTGTTGCTCCAGTCATGGCTTACCCGTAACGG
CATAGACCGTAAGCTCTCTTATCTCTATGTCCAGAATGGCTGGCTCAGACGACTCGCTCATGGCGTTTACTGCCGGACAG
GACGCGAGCCGGACTGGGTGGATGCGGTGTATTGTCTGCAAACACAGTGGGGAAAGCAGATACGGGTGGCGGGGCTGACC
AGTCTTAGGCTACAGGGGTACGCGCACTACATTGAACCGGGCAGGCCGCAGGTCTGGCTTGCGCTTCCGGCCTACGTCAA
ACTGCCGGGGTGGTTCGCGGTCTTTGAACAATCCGCGACGTTTGTCGCACTGTATACGTCGAGTTTAACCGTTGATATAA
CGCCGTTTACTCTGGAACTGAAAATGGGTGACAGGCGGTTGACCGGGAGCGTATCAGAACTTGCCGCCTATGAGATCGCC
TGCGGCGTCCCTTCGTTGATCTCATTCGAACATGCCGATGTGCTGTATCAGGGGATGAACCTTCTCAGCCCACGTAAGCT
GCAGGCGCTGCTCTGCGCCAGCCATTCGGTTAAAACCAATCGGGTGATGCTTTATCTTGCCCAGCGTAATGCGCATCCTT
ATTTTCAGTACCTTAATCAAAACGGTATAGAAACAGGCAAAGGAAAGCGGCAAATCGTTCCCGGCGGCTGGCTTGAGCCG
GATTATCAAATTACCGTTCCCCGCGCGTTTAAACCGGAAGGAACCGACGATGGATCTACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3G1J7

Antitoxin

Source ID Structure
AlphaFold DB E3G1J8

References