Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 961714..962337 Replicon chromosome
Accession NZ_CP099809
Organism Yersinia ruckeri strain NVI-10587

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LNQ46_RS04295 Protein ID WP_038243726.1
Coordinates 961714..961917 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LNQ46_RS04300 Protein ID WP_004718732.1
Coordinates 961969..962337 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNQ46_RS04270 (LNQ46_004270) 957569..957907 + 339 WP_007886947.1 P-II family nitrogen regulator -
LNQ46_RS04275 (LNQ46_004275) 957946..959235 + 1290 WP_004718723.1 ammonium transporter AmtB -
LNQ46_RS04280 (LNQ46_004280) 959350..960213 - 864 WP_248578737.1 acyl-CoA thioesterase II -
LNQ46_RS04285 (LNQ46_004285) 960591..960905 - 315 WP_248577445.1 MGMT family protein -
LNQ46_RS04295 (LNQ46_004295) 961714..961917 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
LNQ46_RS04300 (LNQ46_004300) 961969..962337 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LNQ46_RS04305 (LNQ46_004305) 963386..963547 + 162 WP_004718735.1 hypothetical protein -
LNQ46_RS04310 (LNQ46_004310) 963666..963809 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LNQ46_RS04315 (LNQ46_004315) 963829..964083 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T249475 WP_038243726.1 NZ_CP099809:c961917-961714 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT249475 WP_004718732.1 NZ_CP099809:c962337-961969 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References