Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3556846..3557465 Replicon chromosome
Accession NC_014618
Organism Enterobacter lignolyticus SCF1

Toxin (Protein)


Gene name Hha Uniprot ID E3G6B6
Locus tag ENTCL_RS23160 Protein ID WP_013367304.1
Coordinates 3557247..3557465 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E3G6B5
Locus tag ENTCL_RS16600 Protein ID WP_013367303.1
Coordinates 3556846..3557220 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTCL_RS16590 3552004..3553197 + 1194 WP_013367301.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ENTCL_RS16595 3553220..3556366 + 3147 WP_013367302.1 multidrug efflux RND transporter permease subunit -
ENTCL_RS16600 3556846..3557220 + 375 WP_013367303.1 Hha toxicity modulator TomB Antitoxin
ENTCL_RS23160 3557247..3557465 + 219 WP_013367304.1 hemolysin expression modulator Hha Toxin
ENTCL_RS16605 3557619..3558173 + 555 WP_013367305.1 maltose O-acetyltransferase -
ENTCL_RS16610 3558273..3558740 + 468 WP_013367306.1 membrane protein -
ENTCL_RS16615 3558712..3560172 - 1461 WP_013367307.1 PLP-dependent aminotransferase family protein -
ENTCL_RS16620 3560273..3560983 + 711 WP_013367308.1 GNAT family N-acetyltransferase -
ENTCL_RS16625 3560980..3561120 - 141 WP_013367309.1 type B 50S ribosomal protein L36 -
ENTCL_RS16630 3561123..3561383 - 261 WP_013367310.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T24947 WP_013367304.1 NC_014618:3557247-3557465 [[Enterobacter] lignolyticus SCF1]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPVSVWKFIR

Download         Length: 219 bp

>T24947 NC_014618:3557247-3557465 [[Enterobacter] lignolyticus SCF1]
ATGTCAGAGAAACCCTTAACAAAGACTGATTATTTGATGCGTTTGCGACGTTGTCAGACTATTGACACACTGGAACGTGT
CATTGAAAAAAATAAATATGAACTTTCAGACAATGAACTGGCTGTTTTTTACTCAGCCGCCGATCATCGTCTTGCCGAAC
TTACTATGAATAAGCTTTACGATAAAATCCCCGTTTCGGTATGGAAATTCATACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14526.41 Da        Isoelectric Point: 4.9045

>AT24947 WP_013367303.1 NC_014618:3556846-3557220 [[Enterobacter] lignolyticus SCF1]
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEENRAGWVNDPTSAINLQINELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINAEDLQKWRKSGNRLFRCFTNISRANPVSLSC

Download         Length: 375 bp

>AT24947 NC_014618:3556846-3557220 [[Enterobacter] lignolyticus SCF1]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGCCTTGT
TAACCTTGAAGAGAACCGTGCAGGCTGGGTGAACGATCCGACCTCCGCGATTAACCTTCAAATCAACGAACTGATCGAGC
ATATTGCTACCTTCGCACTTAATTACAAAATTAAGTATAACGAAGACAATAAATTGATCGCACAAATTGATGAATATCTG
GACGATACCTTTATGTTGTTCAGTAACTATGGCATTAACGCAGAGGATCTGCAGAAATGGCGAAAATCTGGAAACAGGCT
TTTTCGTTGTTTCACCAACATCAGTAGAGCTAATCCGGTTAGTCTCTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3G6B6

Antitoxin

Source ID Structure
AlphaFold DB A0A806X2P6

References