Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1008970..1009593 Replicon chromosome
Accession NZ_CP099808
Organism Yersinia ruckeri strain NVI-11076

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LNQ41_RS04610 Protein ID WP_038243726.1
Coordinates 1008970..1009173 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LNQ41_RS04615 Protein ID WP_004718732.1
Coordinates 1009225..1009593 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNQ41_RS04585 (LNQ41_004580) 1004825..1005163 + 339 WP_007886947.1 P-II family nitrogen regulator -
LNQ41_RS04590 (LNQ41_004585) 1005202..1006491 + 1290 WP_004718723.1 ammonium transporter AmtB -
LNQ41_RS04595 (LNQ41_004590) 1006606..1007469 - 864 WP_004718726.1 acyl-CoA thioesterase II -
LNQ41_RS04600 (LNQ41_004595) 1007847..1008161 - 315 WP_004718728.1 MGMT family protein -
LNQ41_RS04610 (LNQ41_004605) 1008970..1009173 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
LNQ41_RS04615 (LNQ41_004610) 1009225..1009593 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LNQ41_RS04620 (LNQ41_004615) 1010642..1010803 + 162 WP_004718735.1 hypothetical protein -
LNQ41_RS04625 (LNQ41_004620) 1010922..1011065 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LNQ41_RS04630 (LNQ41_004625) 1011085..1011339 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T249466 WP_038243726.1 NZ_CP099808:c1009173-1008970 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT249466 WP_004718732.1 NZ_CP099808:c1009593-1009225 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References