Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2372494..2373469 Replicon chromosome
Accession NZ_CP099801
Organism Bacillus paranthracis strain SSBC101

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag NHM99_RS12250 Protein ID WP_002027714.1
Coordinates 2372494..2373231 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag NHM99_RS12255 Protein ID WP_000588712.1
Coordinates 2373344..2373469 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHM99_RS12220 (NHM99_12220) 2367569..2368279 + 711 WP_000787481.1 class I SAM-dependent methyltransferase -
NHM99_RS12225 (NHM99_12225) 2368399..2368806 + 408 WP_000072484.1 VOC family protein -
NHM99_RS12230 (NHM99_12230) 2368912..2369004 + 93 Protein_2333 methyltransferase -
NHM99_RS12235 (NHM99_12235) 2369126..2370811 - 1686 WP_002027713.1 alpha-keto acid decarboxylase family protein -
NHM99_RS12240 (NHM99_12240) 2370918..2371400 + 483 WP_000191904.1 MarR family transcriptional regulator -
NHM99_RS12245 (NHM99_12245) 2371568..2372305 + 738 WP_000594123.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
NHM99_RS12250 (NHM99_12250) 2372494..2373231 + 738 WP_002027714.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NHM99_RS12255 (NHM99_12255) 2373344..2373469 + 126 WP_000588712.1 hypothetical protein Antitoxin
NHM99_RS12260 (NHM99_12260) 2373545..2373721 + 177 WP_000852618.1 stage II sporulation protein SB -
NHM99_RS12265 (NHM99_12265) 2373865..2375334 + 1470 WP_000287521.1 beta-Ala-His dipeptidase -
NHM99_RS12270 (NHM99_12270) 2375411..2375782 - 372 WP_000670600.1 DUF5065 family protein -
NHM99_RS12275 (NHM99_12275) 2375925..2376518 + 594 WP_253130388.1 SGNH/GDSL hydrolase family protein -
NHM99_RS12280 (NHM99_12280) 2376740..2377273 + 534 WP_000438318.1 sigma-70 family RNA polymerase sigma factor -
NHM99_RS12285 (NHM99_12285) 2377263..2378090 + 828 WP_001060779.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T249452 WP_002027714.1 NZ_CP099801:2372494-2373231 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT249452 WP_000588712.1 NZ_CP099801:2373344-2373469 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M9H7T3

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References