Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 249720..250362 Replicon chromosome
Accession NZ_CP099801
Organism Bacillus paranthracis strain SSBC101

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NHM99_RS01395 Protein ID WP_253130004.1
Coordinates 250012..250362 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag NHM99_RS01390 Protein ID WP_000004570.1
Coordinates 249720..250007 (+) Length 96 a.a.

Genomic Context

NHM99_RS01365NHM99_RS01375NHM99_RS01380NHM99_RS01385NHM99_RS01390NHM99_RS01395NHM99_RS01400NHM99_RS01410NHM99_RS01370NHM99_RS01405
Location: 245044..246006 (963 bp)
Type: Others
Protein ID: WP_000961151.1
Location: 246664..247023 (360 bp)
Type: Others
Protein ID: WP_000635037.1
Location: 247180..248130 (951 bp)
Type: Others
Protein ID: WP_025991724.1
Location: 248249..249418 (1170 bp)
Type: Others
Protein ID: WP_000390601.1
Location: 249720..250007 (288 bp)
Type: Antitoxin
Protein ID: WP_000004570.1
Location: 250012..250362 (351 bp)
Type: Toxin
Protein ID: WP_253130004.1
Location: 250430..252598 (2169 bp)
Type: Others
Protein ID: WP_000450602.1
Location: 252968..253426 (459 bp)
Type: Others
Protein ID: WP_000344246.1
Location: 245999..246571 (573 bp)
Type: Others
Protein ID: WP_000906919.1
Location: 252656..252772 (117 bp)
Type: Others
Protein ID: WP_001143642.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NHM99_RS01365 (NHM99_01365)245044..246006+963WP_000961151.1UV DNA damage repair endonuclease UvsE-
NHM99_RS01370 (NHM99_01370)245999..246571-573WP_000906919.1rhomboid family intramembrane serine protease-
NHM99_RS01375 (NHM99_01375)246664..247023+360WP_000635037.1holo-ACP synthase-
NHM99_RS01380 (NHM99_01380)247180..248130+951WP_025991724.1outer membrane lipoprotein carrier protein LolA-
NHM99_RS01385 (NHM99_01385)248249..249418+1170WP_000390601.1alanine racemase-
NHM99_RS01390 (NHM99_01390)249720..250007+288WP_000004570.1antitoxin EndoAIAntitoxin
NHM99_RS01395 (NHM99_01395)250012..250362+351WP_253130004.1type II toxin-antitoxin system endoribonuclease NdoAToxin
NHM99_RS01400 (NHM99_01400)250430..252598+2169WP_000450602.1Tex family protein-
NHM99_RS01405 (NHM99_01405)252656..252772-117WP_001143642.1cortex morphogenetic protein CmpA-
NHM99_RS01410 (NHM99_01410)252968..253426+459WP_000344246.1SprT family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13008.14 Da        Isoelectric Point: 5.7168

>T249451 WP_253130004.1 NZ_CP099801:250012-250362 [Bacillus paranthracis]
MFVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT249451 WP_000004570.1 NZ_CP099801:249720-250007 [Bacillus paranthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366FY90

References