Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 249720..250362 Replicon chromosome
Accession NZ_CP099801
Organism Bacillus paranthracis strain SSBC101

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NHM99_RS01395 Protein ID WP_253130004.1
Coordinates 250012..250362 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag NHM99_RS01390 Protein ID WP_000004570.1
Coordinates 249720..250007 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHM99_RS01365 (NHM99_01365) 245044..246006 + 963 WP_000961151.1 UV DNA damage repair endonuclease UvsE -
NHM99_RS01370 (NHM99_01370) 245999..246571 - 573 WP_000906919.1 rhomboid family intramembrane serine protease -
NHM99_RS01375 (NHM99_01375) 246664..247023 + 360 WP_000635037.1 holo-ACP synthase -
NHM99_RS01380 (NHM99_01380) 247180..248130 + 951 WP_025991724.1 outer membrane lipoprotein carrier protein LolA -
NHM99_RS01385 (NHM99_01385) 248249..249418 + 1170 WP_000390601.1 alanine racemase -
NHM99_RS01390 (NHM99_01390) 249720..250007 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
NHM99_RS01395 (NHM99_01395) 250012..250362 + 351 WP_253130004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NHM99_RS01400 (NHM99_01400) 250430..252598 + 2169 WP_000450602.1 Tex family protein -
NHM99_RS01405 (NHM99_01405) 252656..252772 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
NHM99_RS01410 (NHM99_01410) 252968..253426 + 459 WP_000344246.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13008.14 Da        Isoelectric Point: 5.7168

>T249451 WP_253130004.1 NZ_CP099801:250012-250362 [Bacillus paranthracis]
MFVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT249451 WP_000004570.1 NZ_CP099801:249720-250007 [Bacillus paranthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References