249449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4718247..4718855 Replicon chromosome
Accession NZ_CP099798
Organism Pseudomonas aeruginosa strain PAO1-L

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag NHZ68_RS21845 Protein ID WP_003114156.1
Coordinates 4718247..4718594 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag NHZ68_RS21850 Protein ID WP_003114155.1
Coordinates 4718604..4718855 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHZ68_RS21815 (NHZ68_21815) 4713606..4713878 + 273 WP_010895521.1 cysteine-rich CWC family protein -
NHZ68_RS21820 (NHZ68_21820) 4713878..4714570 + 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
NHZ68_RS21825 (NHZ68_21825) 4714706..4715749 + 1044 WP_003098363.1 L,D-transpeptidase -
NHZ68_RS21830 (NHZ68_21830) 4715829..4716566 + 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
NHZ68_RS21835 (NHZ68_21835) 4717018..4717920 + 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
NHZ68_RS21845 (NHZ68_21845) 4718247..4718594 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHZ68_RS21850 (NHZ68_21850) 4718604..4718855 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NHZ68_RS21855 (NHZ68_21855) 4719069..4720052 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
NHZ68_RS21860 (NHZ68_21860) 4720052..4721344 - 1293 WP_003115206.1 hypothetical protein -
NHZ68_RS21865 (NHZ68_21865) 4721574..4722848 - 1275 WP_010895520.1 zonular occludens toxin family protein -
NHZ68_RS21870 (NHZ68_21870) 4722852..4723208 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4718247..4740445 22198


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T249449 WP_003114156.1 NZ_CP099798:c4718594-4718247 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT249449 WP_003114155.1 NZ_CP099798:c4718855-4718604 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References