Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4398453..4399711 Replicon chromosome
Accession NZ_CP099798
Organism Pseudomonas aeruginosa strain PAO1-L

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag NHZ68_RS20260 Protein ID WP_003112528.1
Coordinates 4398453..4399208 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NHZ68_RS20265 Protein ID WP_003086329.1
Coordinates 4399343..4399711 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHZ68_RS20250 (NHZ68_20250) 4393626..4396169 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
NHZ68_RS20255 (NHZ68_20255) 4396324..4397685 - 1362 WP_010895536.1 DNA recombination protein RmuC -
NHZ68_RS20260 (NHZ68_20260) 4398453..4399208 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
NHZ68_RS20265 (NHZ68_20265) 4399343..4399711 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NHZ68_RS20270 (NHZ68_20270) 4399784..4401070 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
NHZ68_RS20275 (NHZ68_20275) 4401126..4402715 - 1590 WP_010895535.1 aldehyde dehydrogenase family protein -
NHZ68_RS20280 (NHZ68_20280) 4402794..4403270 + 477 WP_003112531.1 hypothetical protein -
NHZ68_RS20285 (NHZ68_20285) 4403273..4403548 - 276 WP_010793902.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T249448 WP_003112528.1 NZ_CP099798:c4399208-4398453 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT249448 WP_003086329.1 NZ_CP099798:c4399711-4399343 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References