Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1589592..1591287 Replicon chromosome
Accession NZ_CP099798
Organism Pseudomonas aeruginosa strain PAO1-L

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag NHZ68_RS07405 Protein ID WP_003112901.1
Coordinates 1589592..1590461 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag NHZ68_RS07410 Protein ID WP_003112902.1
Coordinates 1590454..1591287 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHZ68_RS07380 (NHZ68_07380) 1585600..1586451 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
NHZ68_RS07385 (NHZ68_07385) 1586492..1587499 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
NHZ68_RS07390 (NHZ68_07390) 1587496..1588272 + 777 WP_003112898.1 ABC transporter permease -
NHZ68_RS07395 (NHZ68_07395) 1588278..1589039 + 762 WP_003112899.1 SDR family oxidoreductase -
NHZ68_RS07400 (NHZ68_07400) 1589053..1589583 + 531 WP_003112900.1 cupin domain-containing protein -
NHZ68_RS07405 (NHZ68_07405) 1589592..1590461 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
NHZ68_RS07410 (NHZ68_07410) 1590454..1591287 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
NHZ68_RS07415 (NHZ68_07415) 1591274..1592071 + 798 WP_003112903.1 SDR family oxidoreductase -
NHZ68_RS07420 (NHZ68_07420) 1592064..1593746 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
NHZ68_RS07425 (NHZ68_07425) 1593757..1594560 + 804 WP_003112905.1 aspartate dehydrogenase -
NHZ68_RS07430 (NHZ68_07430) 1594572..1596056 + 1485 WP_003112906.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T249445 WP_003112901.1 NZ_CP099798:1589592-1590461 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT249445 WP_003112902.1 NZ_CP099798:1590454-1591287 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References