Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3466074..3467295 | Replicon | chromosome |
| Accession | NZ_CP099797 | ||
| Organism | Pseudomonas aeruginosa strain PAO1-N | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | NHZ69_RS15890 | Protein ID | WP_003114949.1 |
| Coordinates | 3466717..3467295 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | NHZ69_RS15885 | Protein ID | WP_003088112.1 |
| Coordinates | 3466074..3466628 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NHZ69_RS15860 (NHZ69_15860) | 3461642..3462193 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| NHZ69_RS15865 (NHZ69_15865) | 3462190..3462588 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| NHZ69_RS15870 (NHZ69_15870) | 3462601..3462924 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| NHZ69_RS15875 (NHZ69_15875) | 3463255..3463716 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| NHZ69_RS15880 (NHZ69_15880) | 3463721..3465916 | + | 2196 | WP_003114948.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| NHZ69_RS15885 (NHZ69_15885) | 3466074..3466628 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| NHZ69_RS15890 (NHZ69_15890) | 3466717..3467295 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| NHZ69_RS15895 (NHZ69_15895) | 3467403..3468590 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| NHZ69_RS15900 (NHZ69_15900) | 3468580..3470751 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| NHZ69_RS15905 (NHZ69_15905) | 3470741..3472018 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T249440 WP_003114949.1 NZ_CP099797:3466717-3467295 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT249440 WP_003088112.1 NZ_CP099797:3466074-3466628 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|