Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1589598..1591293 Replicon chromosome
Accession NZ_CP099797
Organism Pseudomonas aeruginosa strain PAO1-N

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag NHZ69_RS07410 Protein ID WP_003112901.1
Coordinates 1589598..1590467 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag NHZ69_RS07415 Protein ID WP_003112902.1
Coordinates 1590460..1591293 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHZ69_RS07385 (NHZ69_07385) 1585606..1586457 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
NHZ69_RS07390 (NHZ69_07390) 1586498..1587505 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
NHZ69_RS07395 (NHZ69_07395) 1587502..1588278 + 777 WP_003112898.1 ABC transporter permease -
NHZ69_RS07400 (NHZ69_07400) 1588284..1589045 + 762 WP_003112899.1 SDR family oxidoreductase -
NHZ69_RS07405 (NHZ69_07405) 1589059..1589589 + 531 WP_003112900.1 cupin domain-containing protein -
NHZ69_RS07410 (NHZ69_07410) 1589598..1590467 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
NHZ69_RS07415 (NHZ69_07415) 1590460..1591293 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
NHZ69_RS07420 (NHZ69_07420) 1591280..1592077 + 798 WP_003112903.1 SDR family oxidoreductase -
NHZ69_RS07425 (NHZ69_07425) 1592070..1593752 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
NHZ69_RS07430 (NHZ69_07430) 1593763..1594566 + 804 WP_003112905.1 aspartate dehydrogenase -
NHZ69_RS07435 (NHZ69_07435) 1594578..1596062 + 1485 WP_003112906.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T249438 WP_003112901.1 NZ_CP099797:1589598-1590467 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT249438 WP_003112902.1 NZ_CP099797:1590460-1591293 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References