249437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143567..144072 Replicon chromosome
Accession NZ_CP099797
Organism Pseudomonas aeruginosa strain PAO1-N

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag NHZ69_RS00660 Protein ID WP_003083773.1
Coordinates 143567..143848 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag NHZ69_RS00665 Protein ID WP_003112628.1
Coordinates 143845..144072 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHZ69_RS00635 (NHZ69_00635) 138818..140167 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
NHZ69_RS00640 (NHZ69_00640) 140216..140902 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
NHZ69_RS00645 (NHZ69_00645) 141003..141737 + 735 WP_003115036.1 GntR family transcriptional regulator -
NHZ69_RS00650 (NHZ69_00650) 141917..142327 + 411 WP_003101225.1 aegerolysin family protein -
NHZ69_RS00655 (NHZ69_00655) 142359..143267 - 909 WP_003083769.1 LysR family transcriptional regulator -
NHZ69_RS00660 (NHZ69_00660) 143567..143848 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
NHZ69_RS00665 (NHZ69_00665) 143845..144072 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
NHZ69_RS00670 (NHZ69_00670) 144248..144868 - 621 WP_003101226.1 hypothetical protein -
NHZ69_RS00675 (NHZ69_00675) 144969..145469 + 501 WP_003112629.1 LEA type 2 family protein -
NHZ69_RS00680 (NHZ69_00680) 145542..145883 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
NHZ69_RS00685 (NHZ69_00685) 145965..147392 - 1428 WP_003083784.1 GABA permease -
NHZ69_RS00690 (NHZ69_00690) 147561..149054 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T249437 WP_003083773.1 NZ_CP099797:c143848-143567 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT249437 WP_003112628.1 NZ_CP099797:c144072-143845 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References