Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4701981..4702906 Replicon chromosome
Accession NZ_CP099754
Organism Escherichia coli strain 806883-9-2019

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NH020_RS22760 Protein ID WP_014640052.1
Coordinates 4701981..4702367 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag NH020_RS22765 Protein ID WP_024174200.1
Coordinates 4702397..4702906 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH020_RS22725 (4697546) 4697546..4697746 - 201 WP_021527487.1 YdaS family helix-turn-helix protein -
NH020_RS22730 (4697837) 4697837..4698511 + 675 WP_021530636.1 LexA family transcriptional regulator -
NH020_RS22735 (4699179) 4699179..4699541 + 363 WP_000135680.1 protein YfdP -
NH020_RS22740 (4699607) 4699607..4700431 + 825 WP_023908886.1 DUF2303 family protein -
NH020_RS22745 (4700620) 4700620..4701402 + 783 WP_023908887.1 hypothetical protein -
NH020_RS22750 (4701439) 4701439..4701720 + 282 WP_001093916.1 pyocin activator PrtN family protein -
NH020_RS22755 (4701768) 4701768..4701941 - 174 WP_023908888.1 hypothetical protein -
NH020_RS22760 (4701981) 4701981..4702367 - 387 WP_014640052.1 hypothetical protein Toxin
NH020_RS22765 (4702397) 4702397..4702906 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
NH020_RS22770 (4703223) 4703223..4703327 - 105 Protein_4465 tRNA-dihydrouridine synthase -
NH020_RS22775 (4703689) 4703689..4704693 - 1005 WP_022646425.1 DUF2713 family protein -
NH020_RS22780 (4705011) 4705011..4705526 + 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
NH020_RS22785 (4705568) 4705568..4705777 - 210 WP_001296638.1 CsbD family protein -
NH020_RS22790 (4705893) 4705893..4707218 - 1326 WP_001361471.1 MATE family efflux transporter DinF -
NH020_RS22795 (4707291) 4707291..4707899 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4659923..4707899 47976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T249433 WP_014640052.1 NZ_CP099754:c4702367-4701981 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT249433 WP_024174200.1 NZ_CP099754:c4702906-4702397 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References