Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4431663..4432258 Replicon chromosome
Accession NZ_CP099754
Organism Escherichia coli strain 806883-9-2019

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag NH020_RS21350 Protein ID WP_000239581.1
Coordinates 4431663..4432013 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NH020_RS21355 Protein ID WP_001223213.1
Coordinates 4432007..4432258 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH020_RS21330 (4427117) 4427117..4428139 - 1023 WP_001298067.1 ABC transporter permease -
NH020_RS21335 (4428153) 4428153..4429655 - 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
NH020_RS21340 (4429788) 4429788..4430744 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NH020_RS21345 (4431054) 4431054..4431584 + 531 WP_000055075.1 inorganic diphosphatase -
NH020_RS21350 (4431663) 4431663..4432013 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
NH020_RS21355 (4432007) 4432007..4432258 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NH020_RS21360 (4432470) 4432470..4432811 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NH020_RS21365 (4432814) 4432814..4436593 - 3780 WP_022646473.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T249430 WP_000239581.1 NZ_CP099754:c4432013-4431663 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT249430 WP_001223213.1 NZ_CP099754:c4432258-4432007 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References