Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3777699..3778317 Replicon chromosome
Accession NZ_CP099754
Organism Escherichia coli strain 806883-9-2019

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NH020_RS18210 Protein ID WP_001291435.1
Coordinates 3778099..3778317 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NH020_RS18205 Protein ID WP_000344800.1
Coordinates 3777699..3778073 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH020_RS18195 (3772788) 3772788..3773981 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NH020_RS18200 (3774004) 3774004..3777153 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NH020_RS18205 (3777699) 3777699..3778073 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NH020_RS18210 (3778099) 3778099..3778317 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NH020_RS18215 (3778489) 3778489..3779040 + 552 WP_000102574.1 maltose O-acetyltransferase -
NH020_RS18220 (3779156) 3779156..3779626 + 471 WP_022645280.1 YlaC family protein -
NH020_RS18225 (3779790) 3779790..3781340 + 1551 WP_022645279.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NH020_RS18230 (3781382) 3781382..3781735 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NH020_RS18240 (3782114) 3782114..3782425 + 312 WP_000409911.1 MGMT family protein -
NH020_RS18245 (3782456) 3782456..3783028 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T249426 WP_001291435.1 NZ_CP099754:3778099-3778317 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT249426 WP_000344800.1 NZ_CP099754:3777699-3778073 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References