Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3335781..3336486 Replicon chromosome
Accession NZ_CP099754
Organism Escherichia coli strain 806883-9-2019

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NH020_RS16020 Protein ID WP_000539521.1
Coordinates 3335781..3336167 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NH020_RS16025 Protein ID WP_001280945.1
Coordinates 3336157..3336486 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH020_RS16000 (3331785) 3331785..3332411 + 627 WP_001295292.1 glutathione S-transferase GstB -
NH020_RS16005 (3332408) 3332408..3333523 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
NH020_RS16010 (3333634) 3333634..3334017 - 384 WP_000497137.1 biofilm formation regulator BssR -
NH020_RS16015 (3334230) 3334230..3335555 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NH020_RS16020 (3335781) 3335781..3336167 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NH020_RS16025 (3336157) 3336157..3336486 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NH020_RS16030 (3336556) 3336556..3337884 - 1329 WP_022645414.1 GGDEF domain-containing protein -
NH020_RS16035 (3337892) 3337892..3340240 - 2349 WP_022645413.1 EAL domain-containing protein -
NH020_RS16040 (3340417) 3340417..3341328 - 912 WP_044781989.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T249424 WP_000539521.1 NZ_CP099754:3335781-3336167 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT249424 WP_001280945.1 NZ_CP099754:3336157-3336486 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References