Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1141567..1142150 Replicon chromosome
Accession NZ_CP099754
Organism Escherichia coli strain 806883-9-2019

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NH020_RS05440 Protein ID WP_023908984.1
Coordinates 1141815..1142150 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag NH020_RS05435 Protein ID WP_000581937.1
Coordinates 1141567..1141815 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH020_RS05425 (1137906) 1137906..1139207 + 1302 WP_000046818.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
NH020_RS05430 (1139255) 1139255..1141489 + 2235 WP_000226815.1 GTP pyrophosphokinase -
NH020_RS05435 (1141567) 1141567..1141815 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NH020_RS05440 (1141815) 1141815..1142150 + 336 WP_023908984.1 endoribonuclease MazF Toxin
NH020_RS05445 (1142222) 1142222..1143013 + 792 WP_001071641.1 nucleoside triphosphate pyrophosphohydrolase -
NH020_RS05450 (1143241) 1143241..1144878 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
NH020_RS05455 (1144965) 1144965..1146263 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12082.92 Da        Isoelectric Point: 8.2618

>T249417 WP_023908984.1 NZ_CP099754:1141815-1142150 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCQCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT249417 WP_000581937.1 NZ_CP099754:1141567-1141815 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References