Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 990901..991555 Replicon chromosome
Accession NZ_CP099754
Organism Escherichia coli strain 806883-9-2019

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NH020_RS04770 Protein ID WP_000244781.1
Coordinates 991148..991555 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NH020_RS04765 Protein ID WP_000354046.1
Coordinates 990901..991167 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH020_RS04745 (986979) 986979..988412 - 1434 WP_022646090.1 6-phospho-beta-glucosidase BglA -
NH020_RS04750 (988457) 988457..988768 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
NH020_RS04755 (988932) 988932..989591 + 660 WP_000250269.1 hemolysin III family protein -
NH020_RS04760 (989668) 989668..990648 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
NH020_RS04765 (990901) 990901..991167 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NH020_RS04770 (991148) 991148..991555 + 408 WP_000244781.1 protein YgfX Toxin
NH020_RS04775 (991595) 991595..992116 - 522 WP_001055874.1 flavodoxin FldB -
NH020_RS04780 (992228) 992228..993124 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NH020_RS04785 (993149) 993149..993859 + 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NH020_RS04790 (993865) 993865..995598 + 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T249416 WP_000244781.1 NZ_CP099754:991148-991555 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT249416 WP_000354046.1 NZ_CP099754:990901-991167 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References