Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4288231..4288856 Replicon chromosome
Accession NZ_CP099752
Organism Escherichia coli strain 806883-11-2019

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NHF43_RS20605 Protein ID WP_000911329.1
Coordinates 4288458..4288856 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NHF43_RS20600 Protein ID WP_000450524.1
Coordinates 4288231..4288458 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF43_RS20575 (4284033) 4284033..4284503 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NHF43_RS20580 (4284503) 4284503..4285075 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NHF43_RS20585 (4285221) 4285221..4286099 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NHF43_RS20590 (4286116) 4286116..4287150 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NHF43_RS20595 (4287363) 4287363..4288076 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NHF43_RS20600 (4288231) 4288231..4288458 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NHF43_RS20605 (4288458) 4288458..4288856 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NHF43_RS20610 (4289003) 4289003..4289866 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NHF43_RS20615 (4289881) 4289881..4291896 + 2016 WP_028985187.1 tRNA cytosine(34) acetyltransferase TmcA -
NHF43_RS20620 (4291970) 4291970..4292668 + 699 WP_000679812.1 esterase -
NHF43_RS20625 (4292778) 4292778..4292978 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T249411 WP_000911329.1 NZ_CP099752:4288458-4288856 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT249411 WP_000450524.1 NZ_CP099752:4288231-4288458 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References