Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3266682..3267268 Replicon chromosome
Accession NZ_CP099752
Organism Escherichia coli strain 806883-11-2019

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag NHF43_RS15590 Protein ID WP_042014162.1
Coordinates 3266682..3266912 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NHF43_RS15595 Protein ID WP_000593555.1
Coordinates 3266909..3267268 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF43_RS15580 (3262719) 3262719..3265454 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
NHF43_RS15585 (3265454) 3265454..3266578 + 1125 WP_001216257.1 ABC transporter permease -
NHF43_RS15590 (3266682) 3266682..3266912 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
NHF43_RS15595 (3266909) 3266909..3267268 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NHF43_RS15600 (3267388) 3267388..3267789 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NHF43_RS15605 (3267795) 3267795..3268601 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NHF43_RS15610 (3268598) 3268598..3269362 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NHF43_RS15615 (3269362) 3269362..3270195 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NHF43_RS15620 (3270192) 3270192..3271136 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T249407 WP_042014162.1 NZ_CP099752:3266682-3266912 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT249407 WP_000593555.1 NZ_CP099752:3266909-3267268 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References