Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1715202..1715820 Replicon chromosome
Accession NZ_CP099752
Organism Escherichia coli strain 806883-11-2019

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NHF43_RS08345 Protein ID WP_001291435.1
Coordinates 1715602..1715820 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NHF43_RS08340 Protein ID WP_112013726.1
Coordinates 1715202..1715576 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF43_RS08330 (1710291) 1710291..1711484 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NHF43_RS08335 (1711507) 1711507..1714656 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NHF43_RS08340 (1715202) 1715202..1715576 + 375 WP_112013726.1 Hha toxicity modulator TomB Antitoxin
NHF43_RS08345 (1715602) 1715602..1715820 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NHF43_RS08350 (1715991) 1715991..1716542 + 552 WP_000102564.1 maltose O-acetyltransferase -
NHF43_RS08355 (1716658) 1716658..1717128 + 471 WP_000136192.1 YlaC family protein -
NHF43_RS08360 (1717292) 1717292..1718842 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NHF43_RS08365 (1718884) 1718884..1719237 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NHF43_RS08375 (1719616) 1719616..1719927 + 312 WP_000409911.1 MGMT family protein -
NHF43_RS08380 (1719958) 1719958..1720530 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T249402 WP_001291435.1 NZ_CP099752:1715602-1715820 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.48 Da        Isoelectric Point: 4.7395

>AT249402 WP_112013726.1 NZ_CP099752:1715202-1715576 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNAMKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References