Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 224644..225554 Replicon plasmid p806883-10-2019a
Accession NZ_CP099749
Organism Klebsiella pneumoniae strain 806883-10-2019

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NHF42_RS27065 Protein ID WP_032720191.1
Coordinates 224644..225114 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NHF42_RS27070 Protein ID WP_004026357.1
Coordinates 225111..225554 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF42_RS27045 (NHF42_27030) 220367..220912 + 546 WP_260566382.1 hypothetical protein -
NHF42_RS27050 (NHF42_27035) 220931..222129 + 1199 WP_114502740.1 IS3 family transposase -
NHF42_RS27055 (NHF42_27040) 222398..223402 + 1005 WP_114502738.1 IS110 family transposase -
NHF42_RS27060 (NHF42_27045) 224274..224534 + 261 WP_032720190.1 hypothetical protein -
NHF42_RS27065 (NHF42_27050) 224644..225114 - 471 WP_032720191.1 RES family NAD+ phosphorylase Toxin
NHF42_RS27070 (NHF42_27055) 225111..225554 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NHF42_RS27075 (NHF42_27060) 225655..226401 - 747 Protein_247 DUF4113 domain-containing protein -
NHF42_RS27080 (NHF42_27065) 226400..227992 - 1593 WP_032720193.1 cyclic peptide export ABC transporter -
NHF42_RS27085 (NHF42_27070) 228024..230009 - 1986 WP_032720194.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..243395 243395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17501.76 Da        Isoelectric Point: 4.6155

>T249393 WP_032720191.1 NZ_CP099749:c225114-224644 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWSGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT249393 WP_004026357.1 NZ_CP099749:c225554-225111 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References