Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4798791..4799307 Replicon chromosome
Accession NZ_CP099748
Organism Klebsiella pneumoniae strain 806883-10-2019

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag NHF42_RS23215 Protein ID WP_004894697.1
Coordinates 4798791..4799075 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NHF42_RS23220 Protein ID WP_002886901.1
Coordinates 4799065..4799307 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF42_RS23190 (NHF42_23175) 4794186..4794449 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
NHF42_RS23195 (NHF42_23180) 4794579..4794752 + 174 WP_002886906.1 hypothetical protein -
NHF42_RS23200 (NHF42_23185) 4794755..4795498 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
NHF42_RS23205 (NHF42_23190) 4795856..4797994 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
NHF42_RS23210 (NHF42_23195) 4798323..4798787 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NHF42_RS23215 (NHF42_23200) 4798791..4799075 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHF42_RS23220 (NHF42_23205) 4799065..4799307 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NHF42_RS23225 (NHF42_23210) 4799385..4801295 - 1911 WP_023325426.1 PRD domain-containing protein -
NHF42_RS23230 (NHF42_23215) 4801318..4802472 - 1155 WP_004178372.1 lactonase family protein -
NHF42_RS23235 (NHF42_23220) 4802539..4803279 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T249388 WP_004894697.1 NZ_CP099748:c4799075-4798791 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT249388 WP_002886901.1 NZ_CP099748:c4799307-4799065 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References