Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4707020..4707723 Replicon chromosome
Accession NZ_CP099748
Organism Klebsiella pneumoniae strain 806883-10-2019

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag NHF42_RS22790 Protein ID WP_040196446.1
Coordinates 4707020..4707361 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag NHF42_RS22795 Protein ID WP_040196448.1
Coordinates 4707382..4707723 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF42_RS22765 (NHF42_22750) 4703597..4704724 + 1128 WP_023325431.1 PAAR domain-containing protein -
NHF42_RS22770 (NHF42_22755) 4704714..4704977 + 264 WP_004192273.1 hypothetical protein -
NHF42_RS22775 (NHF42_22760) 4705123..4705257 + 135 Protein_4466 transposase -
NHF42_RS22780 (NHF42_22765) 4705270..4705380 - 111 Protein_4467 DUF4102 domain-containing protein -
NHF42_RS22785 (NHF42_22770) 4705755..4706762 - 1008 WP_004216518.1 restriction endonuclease -
NHF42_RS22790 (NHF42_22775) 4707020..4707361 - 342 WP_040196446.1 TA system toxin CbtA family protein Toxin
NHF42_RS22795 (NHF42_22780) 4707382..4707723 - 342 WP_040196448.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NHF42_RS22800 (NHF42_22785) 4707734..4708276 - 543 WP_004894621.1 DNA repair protein RadC -
NHF42_RS22805 (NHF42_22790) 4708289..4708732 - 444 WP_004894623.1 antirestriction protein -
NHF42_RS22810 (NHF42_22795) 4708763..4709584 - 822 WP_040196452.1 DUF932 domain-containing protein -
NHF42_RS22815 (NHF42_22800) 4709683..4709913 - 231 WP_014226751.1 DUF905 domain-containing protein -
NHF42_RS22820 (NHF42_22805) 4709985..4710434 - 450 WP_004215773.1 IrmA family protein -
NHF42_RS22825 (NHF42_22810) 4710431..4710883 - 453 WP_040196455.1 hypothetical protein -
NHF42_RS22830 (NHF42_22815) 4710920..4711489 - 570 WP_260566371.1 hypothetical protein -
NHF42_RS22835 (NHF42_22820) 4711489..4712193 - 705 WP_040196458.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4699481..4746762 47281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12791.74 Da        Isoelectric Point: 7.1648

>T249387 WP_040196446.1 NZ_CP099748:c4707361-4707020 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12829.33 Da        Isoelectric Point: 5.4792

>AT249387 WP_040196448.1 NZ_CP099748:c4707723-4707382 [Klebsiella pneumoniae]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGDFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAIYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References