Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2637238..2638826 Replicon chromosome
Accession NZ_CP099748
Organism Klebsiella pneumoniae strain 806883-10-2019

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag NHF42_RS12895 Protein ID WP_004892016.1
Coordinates 2637238..2638560 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NHF42_RS12900 Protein ID WP_004176198.1
Coordinates 2638560..2638826 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF42_RS12880 (NHF42_12870) 2632294..2634795 + 2502 WP_004892009.1 fimbria/pilus outer membrane usher protein -
NHF42_RS12885 (NHF42_12875) 2634783..2635787 + 1005 WP_040196186.1 fimbrial protein -
NHF42_RS12890 (NHF42_12880) 2635929..2637221 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NHF42_RS12895 (NHF42_12885) 2637238..2638560 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
NHF42_RS12900 (NHF42_12890) 2638560..2638826 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NHF42_RS12905 (NHF42_12895) 2639091..2639417 - 327 WP_004892019.1 hydroxyisourate hydrolase -
NHF42_RS12910 (NHF42_12900) 2639414..2639914 - 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NHF42_RS12915 (NHF42_12905) 2639892..2641271 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
NHF42_RS12920 (NHF42_12910) 2641617..2642771 + 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
NHF42_RS12925 (NHF42_12915) 2642752..2643675 - 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T249383 WP_004892016.1 NZ_CP099748:c2638560-2637238 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT249383 WP_004176198.1 NZ_CP099748:c2638826-2638560 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References