Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 224905..225815 Replicon plasmid p503666-2-2019a
Accession NZ_CP099744
Organism Klebsiella pneumoniae strain 503666-2-2019

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NHF44_RS26890 Protein ID WP_032720191.1
Coordinates 224905..225375 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NHF44_RS26895 Protein ID WP_004026357.1
Coordinates 225372..225815 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF44_RS26870 (NHF44_26855) 220628..221173 + 546 WP_260566382.1 hypothetical protein -
NHF44_RS26875 (NHF44_26860) 221192..222390 + 1199 WP_114502740.1 IS3 family transposase -
NHF44_RS26880 (NHF44_26865) 222659..223663 + 1005 WP_114502738.1 IS110 family transposase -
NHF44_RS26885 (NHF44_26870) 224535..224795 + 261 WP_032720190.1 hypothetical protein -
NHF44_RS26890 (NHF44_26875) 224905..225375 - 471 WP_032720191.1 RES family NAD+ phosphorylase Toxin
NHF44_RS26895 (NHF44_26880) 225372..225815 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NHF44_RS26900 (NHF44_26885) 225916..226662 - 747 Protein_246 DUF4113 domain-containing protein -
NHF44_RS26905 (NHF44_26890) 226661..228253 - 1593 WP_032720193.1 cyclic peptide export ABC transporter -
NHF44_RS26910 (NHF44_26895) 228285..230270 - 1986 WP_032720194.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..243656 243656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17501.76 Da        Isoelectric Point: 4.6155

>T249374 WP_032720191.1 NZ_CP099744:c225375-224905 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWSGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT249374 WP_004026357.1 NZ_CP099744:c225815-225372 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References