Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 40310..40953 Replicon plasmid p503666-2-2019a
Accession NZ_CP099744
Organism Klebsiella pneumoniae strain 503666-2-2019

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NHF44_RS25875 Protein ID WP_044266737.1
Coordinates 40537..40953 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID G8LQB1
Locus tag NHF44_RS25870 Protein ID WP_007853351.1
Coordinates 40310..40540 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF44_RS25840 (NHF44_25825) 35942..36978 - 1037 Protein_34 lasso peptide isopeptide bond-forming cyclase -
NHF44_RS25845 (NHF44_25830) 37012..37980 + 969 WP_004099053.1 IS5-like element IS903B family transposase -
NHF44_RS25850 (NHF44_25835) 38035..38595 - 561 Protein_36 lasso peptide isopeptide bond-forming cyclase -
NHF44_RS25855 (NHF44_25840) 38596..39213 - 618 WP_260566387.1 lasso peptide biosynthesis B2 protein -
NHF44_RS25860 (NHF44_25845) 39282..39419 - 138 WP_023341729.1 lasso peptide klebsidin -
NHF44_RS25865 (NHF44_25850) 40160..40353 - 194 Protein_39 hypothetical protein -
NHF44_RS25870 (NHF44_25855) 40310..40540 + 231 WP_007853351.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NHF44_RS25875 (NHF44_25860) 40537..40953 + 417 WP_044266737.1 type II toxin-antitoxin system VapC family toxin Toxin
NHF44_RS25880 (NHF44_25865) 41112..43250 - 2139 WP_260566388.1 AAA family ATPase -
NHF44_RS25885 (NHF44_25870) 44033..45235 - 1203 WP_260566389.1 arabinose transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..243656 243656
- flank IS/Tn - - 45260..46183 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15121.55 Da        Isoelectric Point: 7.8882

>T249371 WP_044266737.1 NZ_CP099744:40537-40953 [Klebsiella pneumoniae]
VNRIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCTRLDAILPWDRA
AVDATTEIKVALRLAGTPIGANDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8674.77 Da        Isoelectric Point: 4.4692

>AT249371 WP_007853351.1 NZ_CP099744:40310-40540 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3A3Z894

References