Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4668024..4668727 Replicon chromosome
Accession NZ_CP099743
Organism Klebsiella pneumoniae strain 503666-2-2019

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag NHF44_RS22620 Protein ID WP_040196446.1
Coordinates 4668024..4668365 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag NHF44_RS22625 Protein ID WP_040196448.1
Coordinates 4668386..4668727 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF44_RS22595 (NHF44_22580) 4664601..4665728 + 1128 WP_023325431.1 PAAR domain-containing protein -
NHF44_RS22600 (NHF44_22585) 4665718..4665981 + 264 WP_004192273.1 hypothetical protein -
NHF44_RS22605 (NHF44_22590) 4666127..4666261 + 135 Protein_4432 transposase -
NHF44_RS22610 (NHF44_22595) 4666274..4666384 - 111 Protein_4433 DUF4102 domain-containing protein -
NHF44_RS22615 (NHF44_22600) 4666759..4667766 - 1008 WP_004216518.1 restriction endonuclease -
NHF44_RS22620 (NHF44_22605) 4668024..4668365 - 342 WP_040196446.1 TA system toxin CbtA family protein Toxin
NHF44_RS22625 (NHF44_22610) 4668386..4668727 - 342 WP_040196448.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NHF44_RS22630 (NHF44_22615) 4668738..4669280 - 543 WP_004894621.1 DNA repair protein RadC -
NHF44_RS22635 (NHF44_22620) 4669293..4669736 - 444 WP_004894623.1 antirestriction protein -
NHF44_RS22640 (NHF44_22625) 4669767..4670588 - 822 WP_040196452.1 DUF932 domain-containing protein -
NHF44_RS22645 (NHF44_22630) 4670687..4670917 - 231 WP_014226751.1 DUF905 domain-containing protein -
NHF44_RS22650 (NHF44_22635) 4670989..4671438 - 450 WP_004215773.1 IrmA family protein -
NHF44_RS22655 (NHF44_22640) 4671435..4671887 - 453 WP_040196455.1 hypothetical protein -
NHF44_RS22660 (NHF44_22645) 4671924..4672493 - 570 WP_260566371.1 hypothetical protein -
NHF44_RS22665 (NHF44_22650) 4672493..4673197 - 705 WP_040196458.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4660485..4707766 47281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12791.74 Da        Isoelectric Point: 7.1648

>T249368 WP_040196446.1 NZ_CP099743:c4668365-4668024 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12829.33 Da        Isoelectric Point: 5.4792

>AT249368 WP_040196448.1 NZ_CP099743:c4668727-4668386 [Klebsiella pneumoniae]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGDFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAIYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References