Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2637098..2638686 Replicon chromosome
Accession NZ_CP099743
Organism Klebsiella pneumoniae strain 503666-2-2019

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag NHF44_RS12905 Protein ID WP_004892016.1
Coordinates 2637098..2638420 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NHF44_RS12910 Protein ID WP_004176198.1
Coordinates 2638420..2638686 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF44_RS12890 (NHF44_12880) 2632154..2634655 + 2502 WP_004892009.1 fimbria/pilus outer membrane usher protein -
NHF44_RS12895 (NHF44_12885) 2634643..2635647 + 1005 WP_040196186.1 fimbrial protein -
NHF44_RS12900 (NHF44_12890) 2635789..2637081 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NHF44_RS12905 (NHF44_12895) 2637098..2638420 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
NHF44_RS12910 (NHF44_12900) 2638420..2638686 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NHF44_RS12915 (NHF44_12905) 2638951..2639277 - 327 WP_004892019.1 hydroxyisourate hydrolase -
NHF44_RS12920 (NHF44_12910) 2639274..2639774 - 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NHF44_RS12925 (NHF44_12915) 2639752..2641131 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
NHF44_RS12930 (NHF44_12920) 2641477..2642631 + 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
NHF44_RS12935 (NHF44_12925) 2642612..2643535 - 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T249364 WP_004892016.1 NZ_CP099743:c2638420-2637098 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT249364 WP_004176198.1 NZ_CP099743:c2638686-2638420 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References