Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1707935..1708566 Replicon chromosome
Accession NC_014618
Organism Enterobacter lignolyticus SCF1

Toxin (Protein)


Gene name hicA Uniprot ID E3GCU0
Locus tag ENTCL_RS22830 Protein ID WP_013365614.1
Coordinates 1707935..1708210 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E3GCU1
Locus tag ENTCL_RS08020 Protein ID WP_013365615.1
Coordinates 1708207..1708566 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTCL_RS08000 1704521..1705864 + 1344 WP_013365610.1 fimbrial protein -
ENTCL_RS08005 1705836..1706528 + 693 WP_013365611.1 fimbria/pilus periplasmic chaperone -
ENTCL_RS08010 1706584..1707351 + 768 WP_013365612.1 winged helix-turn-helix domain-containing protein -
ENTCL_RS08015 1707461..1707808 + 348 WP_049940962.1 hypothetical protein -
ENTCL_RS22830 1707935..1708210 + 276 WP_013365614.1 type II toxin-antitoxin system HicA family toxin Toxin
ENTCL_RS08020 1708207..1708566 + 360 WP_013365615.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ENTCL_RS08025 1709229..1711445 - 2217 WP_013365616.1 AAA family ATPase -
ENTCL_RS08030 1711502..1711939 - 438 WP_013365617.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-86)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10080.62 Da        Isoelectric Point: 10.7068

>T24936 WP_013365614.1 NC_014618:1707935-1708210 [[Enterobacter] lignolyticus SCF1]
MKERVSLLRKKQKSTLEQIFKSPAQSGIKWADIESMIKALGGEVKEGRGSRCKFLLNGSIASFHRPHTSPDTDKGAVANL
RDWLESTGVKP

Download         Length: 276 bp

>T24936 NC_014618:1707935-1708210 [[Enterobacter] lignolyticus SCF1]
ATGAAAGAGCGCGTTTCATTACTACGGAAGAAACAAAAAAGTACGCTGGAACAAATATTTAAATCACCCGCTCAATCTGG
CATTAAGTGGGCTGATATAGAATCCATGATCAAGGCCTTAGGCGGTGAGGTGAAAGAGGGTCGAGGTTCACGCTGCAAAT
TTCTGCTGAACGGTAGTATTGCCAGTTTCCATCGACCTCATACATCACCGGATACCGATAAAGGCGCAGTAGCCAACCTG
CGTGACTGGCTGGAGAGTACAGGAGTAAAGCCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13207.91 Da        Isoelectric Point: 5.2080

>AT24936 WP_013365615.1 NC_014618:1708207-1708566 [[Enterobacter] lignolyticus SCF1]
MSKASTPNTIEIAGQPAVISYVPELGAFRGKFLGLTGYCDFVSDSIQGLKKEGEISLREYLDDCKAAGIEAYTHQEKIKT
FTLRYPESFGERLTQAAAEHETSVNAYIIETLNERMKHA

Download         Length: 360 bp

>AT24936 NC_014618:1708207-1708566 [[Enterobacter] lignolyticus SCF1]
ATGAGCAAGGCATCAACGCCAAACACGATTGAGATAGCGGGGCAGCCTGCAGTGATTAGCTATGTTCCAGAACTTGGCGC
TTTTCGCGGTAAGTTCCTCGGCCTGACGGGATATTGCGACTTCGTCTCCGACAGTATCCAGGGTCTGAAAAAAGAAGGTG
AGATCTCACTGCGCGAGTACCTTGATGATTGTAAAGCAGCAGGTATTGAGGCCTACACGCATCAGGAGAAAATTAAAACC
TTCACGCTACGTTATCCAGAATCATTTGGAGAGCGTTTAACCCAGGCCGCCGCGGAGCACGAAACGTCGGTAAATGCTTA
TATCATTGAAACGCTCAATGAACGTATGAAACATGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3GCU0

Antitoxin

Source ID Structure
AlphaFold DB A0A806X756

References