Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 796608..797265 Replicon chromosome
Accession NZ_CP099743
Organism Klebsiella pneumoniae strain 503666-2-2019

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NHF44_RS03930 Protein ID WP_002916310.1
Coordinates 796855..797265 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NHF44_RS03925 Protein ID WP_002916312.1
Coordinates 796608..796874 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF44_RS03900 (NHF44_03900) 791764..793197 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NHF44_RS03905 (NHF44_03905) 793316..794044 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NHF44_RS03910 (NHF44_03910) 794094..794405 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NHF44_RS03915 (NHF44_03915) 794569..795228 + 660 WP_002916317.1 hemolysin III family protein -
NHF44_RS03920 (NHF44_03920) 795379..796362 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
NHF44_RS03925 (NHF44_03925) 796608..796874 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NHF44_RS03930 (NHF44_03930) 796855..797265 + 411 WP_002916310.1 protein YgfX Toxin
NHF44_RS03935 (NHF44_03935) 797272..797793 - 522 WP_004144730.1 flavodoxin FldB -
NHF44_RS03940 (NHF44_03940) 797894..798790 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NHF44_RS03945 (NHF44_03945) 798813..799526 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NHF44_RS03950 (NHF44_03950) 799532..801265 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T249359 WP_002916310.1 NZ_CP099743:796855-797265 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT249359 WP_002916312.1 NZ_CP099743:796608-796874 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References